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FLASH GENE

Symbol

IGFALS

contributors: mct/npt - updated : 26-01-2010

HGNC name	insulin-like growth factor binding protein, acid labile subunit
HGNC id	5468

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	3.29 kb     2 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001146006 - - 2282 NP_001139478 - 643 - Deming (2005) NM_004970 2 - 2168 NP_004961 - 605 - Deming (2005)

EXPRESSION

Type	restricted

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver           pancreas exocrine         Lymphoid/Immune thymus         Reproductive female system uterus         female system breast mammary gland

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic plasma

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES		Hydrophobic
STRUCTURE

motifs/domains

27 AA hydrophobic sequence (18 to 20 leucine-rich repeats of 24 AA)

conjugated

GlycoP

HOMOLOGY

interspecies	homolog to rattus Igfals
	homolog to murine Igfals

Homologene

FAMILY

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION

extracellular

basic FUNCTION	involved in protein-protein interactions that result in protein complexes, receptor-ligand binding or cell adhesion
	having a key role in regulating transendothelial IGF transport, but other factors are also involved (Payet 2004)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

signal transduction

a component

key component of the 150-kD IGF circulating ternary complex

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

ALSD

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS