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FLASH GENE

Symbol

GNAI3

contributors: mct/ - updated : 09-05-2014

HGNC name	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3
HGNC id	4387

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

ACDS1

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional         hindered bone marrow cell development and thus reduced production of pre-thymic progenitors tumoral somatic mutation       in germinal centre B-cell constitutional     --low   absence of GNAI2 and GNAI3 in B cells profoundly disturbs the architecture of lymphoid organs with loss of B cell compartments in the spleen, thymus, lymph nodes, and gastrointestinal tract, resulting in a severe disruption of B cell function and a hyper-IgM like syndrome

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS