| basic FUNCTION
| growth hormone 1 (N variants), anabolic and lipolytic |
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stimulating both the differentiation and proliferation of myoblasts, amino acid uptake and protein synthesis in muscle and other tissues |
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exerts metabolic effects both directly and through stimulation of IGF1, insulin, and free fatty acids (FFA)  |
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increases expression of ZEB2 in the glomerular podocyte and also decreases CDH1 expression in these cells |
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GH1/IGF1 is likely to play an important role in the regulation of tendon and muscle collagen |
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induces the activity of RELA (an important member of the NFKB family of transcription factors) in growth plate chondrocytes |
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potent stimulator of longitudinal bone growth |
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stimulates RELA nuclear translocation and DNA binding in growth plate chondrocytes |
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FGF21 and GH1 are metabolic hormones that play important roles in regulating glucose and lipid metabolism |
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GH1/IGF-1 axis is the key regulator of somatic growth |
