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FLASH GENE

Symbol

RAB6A

contributors: mct/shn/pgu - updated : 20-09-2015

HGNC name	RAB6A, member RAS oncogene family
HGNC id	9786

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	85.52 kb     8 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

Map	cen - D11S1314 - D11S916 - RAB6A - D11S2371 - D11S4207 - qter

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_002869 8 - 3419 NP_002860 23.6 208 - PMID: 19141279 NM_198896 8 splicing 3419 NP_942599 23.3 208 - PMID: 19141279

EXPRESSION

Type	ubiquitous

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Lymphoid/Immune thymus         Nervous brain         Respiratory respiratory tract larynx       Urinary bladder

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow       Nervous peripherous

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

binding domains of three RAB6A effector proteins: GOPC, BICD2, and DCTN1

HOMOLOGY

interspecies

homolog to murine Rab 6

Homologene

FAMILY

Rab6 family

CATEGORY

protooncogene , transport carrier

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
	intracellular,cytoplasm,organelle,Golgi

basic FUNCTION	regulates retrograde membrane traffic from endosomes to the Golgi apparatus and from the Golgi to the endoplasmic reticulum (ER)
	regulates vesicle trafficking at the level of Golgi via recruitment of numerous and unrelated effectors
	key regulator in the retrograde transfer from endosomes via the Golgi to the ER
	regulates distinct Golgi trafficking pathways involving two separate protein complexes: ZW10/RINT1 and COG
	implicated in dynein-mediated vesicle movement at the Golgi apparatus and interact with a plethora of effector proteins
	RAB1A and RAB6A may be involved in the regulation of the retinal adaptation
	RAB33B/RAB6A regulated intra-Golgi retrograde trafficking pathway must coexist with other Golgi trafficking pathways
	important role during neuritogenesis
	RAB6A/RAB6B is a conserved small GTPase that localizes to the Golgi apparatus and cytoplasmic vesicles and controls transport and fusion of secretory carriers
	RAB6A, RAB8A, and MICAL3 cooperate in controlling docking and fusion of exocytotic carriers
	is involved in the trafficking of vesicles at the level of Golgi via interactions with numerous effector proteins

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

cellular trafficking transport

text	non specific vesicle transport

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	RAB6KIFL
	NSF
	DYNLRB1 specifically interacts with all three RAB6 isoforms and co-localises at the Golgi
	RAB33B and RAB6A act to coordinate a major intra-Golgi retrograde trafficking pathway
	DENND5A/DENND5B interacting with RAB6A/RAB6B
	KIF1C transports RAB6A-vesicles and can influence Golgi complex organization
	RAB6A binding to KIF1C motor domain represents an entirely new mode of regulation for a kinesin motor, and likely has important consequences for KIF1C cellular functions

cell & other

REGULATION

activated by

NSF (activation of ATPase activity)

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --low   age-down regulated in the frontal cortex

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS