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FLASH GENE
Symbol RAB6A contributors: mct/shn/pgu - updated : 20-09-2015
HGNC name RAB6A, member RAS oncogene family
HGNC id 9786
Location 11q13.4      Physical location : 73.386.689 - 73.472.201
Synonym name
  • oncogene RAB6
  • ras-related protein rab 6a
  • GTP-binding protein RAB6A
  • GTP-binding protein RAB6B
  • Rab6A variant 3
    • Synonym symbol(s) RAB6, RAB6B, Rab-6
    DNA
    TYPE functioning gene
    STRUCTURE 85.52 kb     8 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map cen - D11S1314 - D11S916 - RAB6A - D11S2371 - D11S4207 - qter
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 3419 23.6 208 - PMID: 19141279
    8 splicing 3419 23.3 208 - PMID: 19141279
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunethymus    
    Nervousbrain    
    Respiratoryrespiratory tractlarynx   
    Urinarybladder    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    Nervousperipherous   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • binding domains of three RAB6A effector proteins: GOPC, BICD2, and DCTN1
    • HOMOLOGY
    interspecies homolog to murine Rab 6
    Homologene
    FAMILY
  • Rab6 family
    • CATEGORY protooncogene , transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    intracellular,cytoplasm,organelle,Golgi
    basic FUNCTION
  • regulates retrograde membrane traffic from endosomes to the Golgi apparatus and from the Golgi to the endoplasmic reticulum (ER)
  • regulates vesicle trafficking at the level of Golgi via recruitment of numerous and unrelated effectors
  • key regulator in the retrograde transfer from endosomes via the Golgi to the ER
  • regulates distinct Golgi trafficking pathways involving two separate protein complexes: ZW10/RINT1 and COG
  • implicated in dynein-mediated vesicle movement at the Golgi apparatus and interact with a plethora of effector proteins
  • RAB1A and RAB6A may be involved in the regulation of the retinal adaptation
  • RAB33B/RAB6A regulated intra-Golgi retrograde trafficking pathway must coexist with other Golgi trafficking pathways
  • important role during neuritogenesis
  • RAB6A/RAB6B is a conserved small GTPase that localizes to the Golgi apparatus and cytoplasmic vesicles and controls transport and fusion of secretory carriers
  • RAB6A, RAB8A, and MICAL3 cooperate in controlling docking and fusion of exocytotic carriers
  • is involved in the trafficking of vesicles at the level of Golgi via interactions with numerous effector proteins
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    text non specific vesicle transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • RAB6KIFL
  • NSF
  • DYNLRB1 specifically interacts with all three RAB6 isoforms and co-localises at the Golgi
  • RAB33B and RAB6A act to coordinate a major intra-Golgi retrograde trafficking pathway
  • DENND5A/DENND5B interacting with RAB6A/RAB6B
  • KIF1C transports RAB6A-vesicles and can influence Golgi complex organization
  • RAB6A binding to KIF1C motor domain represents an entirely new mode of regulation for a kinesin motor, and likely has important consequences for KIF1C cellular functions
    • cell & other
    REGULATION
    activated by NSF (activation of ATPase activity)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    age-down regulated in the frontal cortex
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS