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FLASH GENE
Symbol LMOD3 contributors: mct - updated : 15-05-2018
HGNC name leiomodin 3 (fetal)
HGNC id 6649
Corresponding disease
NEM10 nemaline myopathy 10
Location 3p14.1      Physical location : 69.156.038 - 69.171.746
Synonym name leiomodin, fetal form
Synonym symbol(s) DKFZp313F0135, NEM10
DNA
TYPE functioning gene
STRUCTURE 13.92 kb     3 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
SYNPR 3p14.3 synaptoporin LOC132203 3p21.1 similar to hypothetical protein A430083B19 LOC391542 3 similar to hypothetical protein FLJ23834 LOC132200 3p21.1 hypothetical protein BC015210 NIF3L1BP1 3p21.1 Ngg1 interacting factor 3 like 1 binding protein 1 SCA7 3p13-p12 spinocerebellar ataxia 7 (olivopontocerebellar atrophy with retinal degeneration) p44S10 3p21.1 proteasome regulatory particle subunit p44S10 PRICKLE2 3p21.1 prickle-like 2 (Drosophila) ADAMTS9 3p14.3-p14.2 a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 9 BAIAP1 3p14.1 BAI1-associated protein 1 SLC25A26 3p14.3 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 26 LRIG1 3p14 leucine-rich repeats and immunoglobulin-like domains 1 TA-KRP 3p14 T-cell activation kelch repeat protein SUCLG2 3p14.3 succinate-CoA ligase, GDP-forming, beta subunit LOC375350 3p14.3 COP9 pseudogene LOC151645 3p14.3 protease (prosome, macropain) 26S subunit, ATPase, 1 pseudogene FLJ25161 3p14.3-p14.2 hypothetical protein FLJ25161 LOC152122 3p14.2 hypothetical LOC152122 MGC34132 3p14.2 hypothetical protein MGC34132 TMF1 3p21-p12 TATA element modulatory factor 1 UBE1C 3p24.3-p13 ubiquitin-activating enzyme E1C (UBA3 homolog, yeast) JWA 3p14 ubiquitin-activating enzyme E1C (UBA3 homolog, yeast) LMOD3 3p14.1 leiomodin 3 (fetal) GRSP1 3p14.2 leiomodin 3 (fetal) MITF 3p14.1-p12.3 microphthalmia-associated transcription factor LOC391543 3 similar to KIAA1839 protein FOXP1 3p14.1 forkhead box P1 LOC391544 3 similar to MGC39820 protein GPR27 3p21-p14 G protein-coupled receptor 27 PROK2 3p21.1 prokineticin 2 RYBP 3p13 RING1 and YY1 binding protein LOC339875 3p14.2 hypothetical LOC339875 FLJ10539 3p14.2 hypothetical protein FLJ10539 LOC317753 3p14 proteasome 26S non-ATPase subunit 12 pseudogene LOC389129 3 similar to CG9996-PA PPP4R2 3q28 protein phosphatase 4, regulatory subunit 2 FLJ10213 3p14.1 hypothetical protein FLJ10213 LOC344709 3p14.1 similar to hypothetical protein FLJ38348 SEMACAP3 3p13 similar to hypothetical protein FLJ38348 LOC391546 3 similar to Heat shock protein HSP 90-beta (HSP 84) (HSP 90) ALDRP 3p12 aldehyde reductase (aldose reductase) pseudogene CNTN3 3p26 contactin 3 (plasmacytoma associated)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 2221 64.8 560 - 2014 25250574
3 - 2315 64.8 560 - 2014 25250574
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • tropomodulin family
  • CATEGORY antigen
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton
    basic FUNCTION
  • involved in tropomyosin binding
  • appropriate levels of both TMOD4 and LMOD3 are required for embryonic myofibrillogenesis and, both proteins can function redundantly during skeletal muscle thin filament assembly
  • is required in the fast fibers for sarcomere integrity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • TMOD1 and TMOD4 cap thin filament pointed ends and functionally interact with the LMOD isoforms LMOD2 and LMOD3 to control myofibril organization, thin filament lengths, and actomyosin crossbridge formation in skeletal muscle fibers
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) NEM10
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Lmod3(PB/PB) mice show severe muscle weakness and postnatal growth retardation