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FLASH GENE

Symbol

GP6

contributors: mct/pgu - updated : 27-06-2018

HGNC name	glycoprotein VI (platelet)
HGNC id	14388

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

to platelet hyperaggregability and miscarriage

Variant & Polymorphism SNP	significant higher occurrence of two haplotypes (ACGG, CCGT) increasing the risk of platelet hyperaggregability and miscarriage

Candidate gene
Marker	platelet GP6 surface expression is enhanced in patients at risk for an acute coronary syndrome and is an early marker for imminent acute coronary events in patients with chest pain
	measurement of soluble GP6 level is considered to be important for the diagnosis and evaluation of thrombotic microangiopathy (TMA)
Therapy target
	System Type Disorder Pubmed blood coagulation   ectodomain shedding of GPVI can be mediated through multiple differentially regulated platelet-expressed proteinases with obvious therapeutic implications in thrombosis blood coagulation   Blockade of collagen binding to GPVI would prevent initial adhesion and further activation of the platelet and would have an enormous impact in antithrombotic therapy

ANIMAL & CELL MODELS