motifs/domains
| cytoplasmic N terminus, with a region of amino acids 1-191 interacting with PTPN1 (Sternfeld 2007), extended N terminus  |
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three ankyrin repeats multiple phosphrylation sites |
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six transmembrane spanning ankyrin repeats domains, six ankyrin-like repeats in the TRPV6 N-terminal |
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a putative pore-forming region between transmembrane domains 5 and 6 |
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a C terminal cytoplasmic domain, with PDZ (Post-synaptic density-95, Drosophila discs-large protein, Zonula occludens protein 1) binding motif |
| basic FUNCTION
| playing a role in 1,25(OH)(2)D(3)-stimulated Ca(2+) reabsorption in the kidney |
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increasing the rate of Ca(2+) dependent cell proliferation which is a prerequisite for its potential role in tumor progression |
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play a role in the intestinal Ca2+ absorption from food, and in the Ca2+ uptake by the epididymal epithelium |
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being a prerequisite for keratinocyte entry into differentiation |
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duodenal TRPV6 expression is vitamin D dependent in men, but not in older women, where expression of TRPV6 and VDR are both reduced |
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may participate in Ca2+ transport and/or Ca2+ signaling processes |
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exhibited a lower efficiency of membrane expression and the majority of channel proteins in the plasma membrane were in core-glycosylated form |
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important function of TRPV6 is the Ca2+ uptake in the small intestine, kidney, and bone |
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not required for vitamin D-induced intestinal calcium absorption and may not carry out a significant role in this process (Kutuzova 2008) |
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could function in retinal pigment epithelium to mediate calcium influx from subretinal space and thus regulate changes in subretinal space calcium composition that accompany light/dark transitions |
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calcium supply is limited and in this condition indirectly regulates bone formation and/or mineralization |
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mediates the first step of transcellular Ca2+ transport and is considered to be a gatekeeper for active Ca2+ absorption |
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potentially involved in male fertility depending on Ca2+ absorption by TRPV6 in epididymal epithelia |
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function as epithelial Ca(2+) entry pathways in the epididymis, prostate, and placenta |
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TRPV5 and TRPV6 are crucial gates controlling cadmium and zinc levels in the human body especially under low calcium dietary conditions, when these channels are maximally upregulated |
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is a novel cell adhesion molecule (CAM) that directly regulates endothelial integrity and mediates the protective actions of L-Arg to endothelium via a NO-independent mechanism |
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TRPV5 and TRPV6 play vital roles in calcium homeostasis as Ca(2+) uptake channels in epithelial tissues |
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play a critical role in calcium uptake in epithelial tissues |
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TRPV6 channels are constitutively active and their open probability depends on the lipidic composition of the membrane in which they reside |
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