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FLASH GENE

Symbol

DLL3

contributors: mct/pgu - updated : 27-09-2011

HGNC name	delta-like 3 (Drosophila)
HGNC id	2909

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

SCDO1

Susceptibility

to vertebral malformations

Variant & Polymorphism other	"G" to "A" missense mutation changing glycine to arginine at codon 269, may be associated to vertebral malformations

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

targeted deletion of Dll3 in the mouse causes a developmental defect in somite segmentation, and consequently vertebral formation is severely disrupted, closely resembling human SCD