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FLASH GENE

Symbol

TNFRSF13B

contributors: mct/npt - updated : 20-09-2013

HGNC name	tumor necrosis factor receptor superfamily, member 13B
HGNC id	18153

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

CVID2

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target	for B cell-mediated autoimmune diseases such as systemic lupus erythematosus (Xia 2000)

ANIMAL & CELL MODELS

	inactivation in mice results in a SLE-like phenotype (Salzer 2007)
	Taci-/- mice had increased numbers of B cells but exhibited decreased antibody responses to T-cell–independent type II antigens