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FLASH GENE
Symbol TNFRSF13B contributors: mct/npt - updated : 20-09-2013
HGNC name tumor necrosis factor receptor superfamily, member 13B
HGNC id 18153
ASSOCIATED DISORDERS
corresponding disease(s) CVID2
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target for B cell-mediated autoimmune diseases such as systemic lupus erythematosus (Xia 2000)
ANIMAL & CELL MODELS
  • inactivation in mice results in a SLE-like phenotype (Salzer 2007)
  • Taci-/- mice had increased numbers of B cells but exhibited decreased antibody responses to T-cell–independent type II antigens