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FLASH GENE
Symbol SORBS2 contributors: mct - updated : 17-07-2017
HGNC name sorbin and SH3 domain containing 2
HGNC id 24098
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a serine/threonine rich domain
  • several potential Abl phosphorylation sites
  • three C terminal Src homology 3 (SH3) domains
  • a sorbin homologous domain
    • HOMOLOGY
    interspecies ortholog to rattus Argbp2
    Homologene
    FAMILY glycosyl hydrolase 2 family
    CATEGORY adaptor , structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton
    text
  • stress fibers in epithelial cells
  • Z disks of sarcomeres
    • basic FUNCTION
  • potential link between Abl family kinases and the actin cytoskeleton
  • potential modification of contractile or elastic propertie of cardiac sarcomere
  • adapter protein that plays an important role in actin-dependent processes such as cell adhesion and migration
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ABL1, ABL2 (ARG)
  • FMR1 (RNA target of FMR1)
  • MORC2 enhanced the recruitment of EZH2, which promoted the tri-methylation of H3K27, leading to the transcriptional repression of SORBS2
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerdigestivestomach
    is a potential therapeutic target for gastric cancer
    ANIMAL & CELL MODELS