Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Orphanet	Ensembl
	HGNC	UniGene	Nucleotide	OMIM		UCSC

Home Page

FLASH GENE

Symbol

SLURP1

contributors: mct/ - updated : 09-09-2009

HGNC name	secreted LY6/PLAUR domain containing 1
HGNC id	18746

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

MLDD

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   decreased due to gene silencing of different nAChR alpha subunits with small hairpin RNA, suggesting that a positive feedback regulation is altered in malignant cells constitutional     --low   in asthma attenuates its negative regulation of airway inflammation constitutional     --low   in asthma likely disrupts epithelial homeostasis, leading to remodeling of the bronchial epithelium and greater susceptibility to infections, such as influenza and pneumonia

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	changes in SLURP1 expression could serve as a marker of airway damage in asthma
Therapy target

ANIMAL & CELL MODELS

Slurp-1 mRNA is down-regulated in the lungs of asthmatic model mice, as compared to healthy mice