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FLASH GENE
Symbol SLURP1 contributors: mct/ - updated : 09-09-2009
HGNC name secreted LY6/PLAUR domain containing 1
HGNC id 18746
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • lacking the GPI-anchoring signal sequence and at least eight of the ten conserved cysteines
    • mono polymer homomer , dimer
    HOMOLOGY
    Homologene
    FAMILY
  • Ly-6/Upar family
    • CATEGORY tumor suppressor
    SUBCELLULAR LOCALIZATION extracellular
    text secreted
    basic FUNCTION
  • implicated in transmembrane signal transduction, cell activation, and cell adhesion
  • having a biological role in the epidermis to provide fine tuning of the physiologic regulation of keratinocytes functions through the cholinergic pathways
  • may be involved in regulating lymphocyte function via CHRNA-mediated pathways
  • its expression in airway epithelial cells is down-regulated by the presence of interleukin IL13, which is abundant in asthmatic airways and plays a key role in the pathogenesis of asthma
  • positive allosteric modulator of CHRNA7 signaling, that may mitigate such remodeling of the airway epithelium and diminish production of pro-inflammatory cytokines mediated via CHRNA7
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds to CHRNA7 and enhances the amplitude of macroscopic currents induced by acetylcholine, leading to facilitation of apoptosis
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MLDD
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    decreased due to gene silencing of different nAChR alpha subunits with small hairpin RNA, suggesting that a positive feedback regulation is altered in malignant cells
    constitutional     --low  
    in asthma attenuates its negative regulation of airway inflammation
    constitutional     --low  
    in asthma likely disrupts epithelial homeostasis, leading to remodeling of the bronchial epithelium and greater susceptibility to infections, such as influenza and pneumonia
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • changes in SLURP1 expression could serve as a marker of airway damage in asthma
    • Therapy target
    ANIMAL & CELL MODELS
  • Slurp-1 mRNA is down-regulated in the lungs of asthmatic model mice, as compared to healthy mice