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FLASH GENE

Symbol

GPR83

contributors: mct/npt - updated : 06-04-2010

HGNC name	G protein-coupled receptor 83
HGNC id	4523

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	24.11 kb     4 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_016540 4 - 4300 NP_057624 - 423 - De Moerlooze (2000) variant 2 - - - isoform 2 - 443 - Hansen (2010) also called GPR83I4 20 additional aminoacids within GPR83 isoform-4 are involved in Treg induction during inflammatory immune responses

EXPRESSION

Type	restricted

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain limbic system hippocampus       brain forebrain cerebral cortex       brain diencephalon amygdala       brain diencephalon hypothalamus       brain diencephalon thalamus

cells

System Cell Pubmed Species Stage Rna symbol Nervous neuron

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

seven transmembrane segments (7TM)

HOMOLOGY

intraspecies

homolog to NPT2R

Homologene

FAMILY	rhodopsin family
	G-protein coupled receptor 1 family

CATEGORY

receptor membrane G

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	orphan receptor potentially neuropeptide y receptor,
	may be involved in control of emotions and of neuroendocrine, cognitive and motor functions
	having function directly responsive to glucocorticoid signals (Sah 2005)
	potential role in the control of feeding and ingestive behavior, regulation of stress and emotional behavior, learning and memory, and, drug reinforcement and reward (Sah 2005)
	dispensable for regulatory T (Treg) cells development and function (Lu 2007)
	might be critically involved in the peripheral generation of Foxp3+regulatory T cells (Hansen 2006)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS