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FLASH GENE
Symbol GPR83 contributors: mct/npt - updated : 06-04-2010
HGNC name G protein-coupled receptor 83
HGNC id 4523
DNA
TYPE functioning gene
STRUCTURE 24.11 kb     4 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 4300 - 423 - De Moerlooze (2000)
- - - - 443 - Hansen (2010)
  • also called GPR83I4
  • 20 additional aminoacids within GPR83 isoform-4 are involved in Treg induction during inflammatory immune responses
  • EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrainlimbic systemhippocampus  
     brainforebraincerebral cortex  
     braindiencephalonamygdala  
     braindiencephalonhypothalamus  
     braindiencephalonthalamus  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • seven transmembrane segments (7TM)
  • HOMOLOGY
    intraspecies homolog to NPT2R
    Homologene
    FAMILY
  • rhodopsin family
  • G-protein coupled receptor 1 family
  • CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • orphan receptor potentially neuropeptide y receptor,
  • may be involved in control of emotions and of neuroendocrine, cognitive and motor functions
  • having function directly responsive to glucocorticoid signals (Sah 2005)
  • potential role in the control of feeding and ingestive behavior, regulation of stress and emotional behavior, learning and memory, and, drug reinforcement and reward (Sah 2005)
  • dispensable for regulatory T (Treg) cells development and function (Lu 2007)
  • might be critically involved in the peripheral generation of Foxp3+regulatory T cells (Hansen 2006)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS