Selected-GenAtlas references SOURCE GeneCards NCBI Gene Orphanet Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol MEG3 contributors: mct/npt - updated : 22-04-2015
HGNC name maternally expressed 3 (non-protein coding)
HGNC id 14575
DNA
TYPE anonymous DNA segment
STRUCTURE 34.00 kb     9 Exon(s)
regulatory sequence Promoter
Binding site
motif Viral sequence   gene pol
text structure five CTCF binding sites around the promoter of MEG3 (CTCF-binding region may provide a mechanism for the transcriptional regulation of MEG3 and DLK1)
MAPPING cloned Y linked N status provisional
Map cen - DLK1 - MEG3 - RTL1 - MEG8 - TRCD0 - TRCD1 - TRCD2 - qter
Authors Cavaille (02)
regionally located in DLK1-MEG3 (GTL2) reciprocally imprinted region
RNA
TRANSCRIPTS type untranslated
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Digestiveliver   moderately
Endocrinepancreas   moderately
Nervousbrain   highly
Reproductivemale systemprostate  moderately
Respiratorylung   moderately
Urinarykidney   moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
IMPRINTING paternally
text parent-specific methylation of sequences upstream of MEG3
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
HOMOLOGY
interspecies homolog to synthenic to murine distal chromosome 12 Meg3
Homologene
FAMILY
CATEGORY unknown/unspecified
SUBCELLULAR LOCALIZATION     intracellular
basic FUNCTION
  • suppressing tumor cell growth
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • MEF2A directly regulates the MEG3-DIO3 cluster from the MEG3 proximal promoter region
  • reduced expression of MEG3 in liver cancer may activate PI3K/AKT pathway by inhibiting AP1G1 expression
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) UPD14M , UPD14P
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --other  
    biallelic expression in cancer
    tumoral        
    loss of expression in tumors
    tumoral     --low  
    by hypermethylation in acute myeloid leukemia and myelodysplastic syndromes with worse overall prognosis (Benetatos 2010)
    tumoral     --low  
    could promote the proliferative and invasive abilities of hepatoma cells and accelerate cell cycle
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS