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FLASH GENE
Symbol MEG3 contributors: mct/npt - updated : 22-04-2015
HGNC name maternally expressed 3 (non-protein coding)
HGNC id 14575
Corresponding disease
UPD14M chromosome 14 uniparental disomy, maternal
UPD14P chromosome 14 uniparental disomy, paternal
Location 14q32.2      Physical location : 101.292.444 - 101.327.358
Synonym name
  • gene TRAP locus 2
  • maternally expressed 3
  • non-protein coding RNA 23
  • very putative protein from MEG3 locus
    • Synonym symbol(s) GTL2, PRO0518, FLJ31163, FLJ42589, FP504, NCRNA00023, PRO0518, PRO2160
    DNA
    TYPE anonymous DNA segment
    STRUCTURE 34.00 kb     9 Exon(s)
    regulatory sequence Promoter
    Binding site
    motif Viral sequence   gene pol
    text structure five CTCF binding sites around the promoter of MEG3 (CTCF-binding region may provide a mechanism for the transcriptional regulation of MEG3 and DLK1)
    MAPPING cloned Y linked N status provisional
    Map cen - DLK1 - MEG3 - RTL1 - MEG8 - TRCD0 - TRCD1 - TRCD2 - qter
    Authors Cavaille (02)
    regionally located in DLK1-MEG3 (GTL2) reciprocally imprinted region
    RNA
    TRANSCRIPTS type untranslated
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestiveliver   moderately
    Endocrinepancreas   moderately
    Nervousbrain   highly
    Reproductivemale systemprostate  moderately
    Respiratorylung   moderately
    Urinarykidney   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    IMPRINTING paternally
    text parent-specific methylation of sequences upstream of MEG3
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    HOMOLOGY
    interspecies homolog to synthenic to murine distal chromosome 12 Meg3
    Homologene
    FAMILY
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    basic FUNCTION
  • suppressing tumor cell growth
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • MEF2A directly regulates the MEG3-DIO3 cluster from the MEG3 proximal promoter region
  • reduced expression of MEG3 in liver cancer may activate PI3K/AKT pathway by inhibiting AP1G1 expression
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) UPD14M , UPD14P
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --other  
    biallelic expression in cancer
    tumoral        
    loss of expression in tumors
    tumoral     --low  
    by hypermethylation in acute myeloid leukemia and myelodysplastic syndromes with worse overall prognosis (Benetatos 2010)
    tumoral     --low  
    could promote the proliferative and invasive abilities of hepatoma cells and accelerate cell cycle
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS