| basic FUNCTION
| deacetylates alpha-tubulin and increases cell motility |
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zinc-dependent deacetylases, playing a role in transcriptional regulation cell cycle progression, cell signaling and homeostasis |
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component of the aggresome, playing a crucial role in the cellular management of misfolded protein-induced stress |
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having functions in various cellular processes that are dependent and independent of its catalytic activity and affects cell growth, migration, and cell death |
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invoved in deacetylation of redox regulatory proteins PRDX1 and PRDX2 |
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function as an alpha-tubulin deacetylase and it associates with microtubules and colocalizes with a microtubule motor complex |
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has roles in various microtubule-dependent cytoplasmic processes |
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influences actin-dependent cell motility by altering the acetylation status of cortactin, which, in turn, changes the F-actin binding activity of cortactin  |
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tubulin-specific deacetylase that regulates microtubule-dependent cell movement |
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central component of the stress response, and may coordinates the formation of stress granules (SG) by mediating the motor-protein-driven movement of individual SG components along microtubules |
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regulates many important biological processes, including cell migration, immune synapse formation, viral infection, and the degradation of misfolded proteins |
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promote autophagy by recruiting cortactin to polyubiquitinated protein aggregates, leading to local actin remodeling and stimulation of autophagosome/lysosome fusion |
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deacetylates tubulin, Hsp90 and cortactin, and forms complexes with other partner proteins |
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potential scaffold functions in the regulation of cell migration and other key biological processes in which the cytoskeleton plays an important role |
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essential component of stress granules, that has key roles in different levels of cellular responses and might also regulate cytoplasmic processes such as macropinocytosis |
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involved in deacetylation of tubulin that modulates dynamics of cellular adhesions |
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promotes the polyubiquitination of CDC20, stimulates activity of CDC20-APC and drives the differentiation of dendrites |
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with FNTB are present in a protein complex together with microtubules |
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critical to the aggregation of poly-ubiquitinated proteins iduced by proteasome inhibition as well as the autophagic degradation of such aggregates |
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HDAC6 can function as a cofactor of LCOR but suggesting that they may act in enhance expressing some target genes |
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modulates fundamental cellular processes via deacetylation of alpha-tubulin, cortactin, molecular chaperones, and other peptides |
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associates with the endosomal compartments and controls epidermal growth factor receptor (EGFR) trafficking and degradation through modulation of tubulin acetylation |
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regulatory factor in the intracellular trafficking network that controls EGFR stability |
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required for efficient cancer cell growth and tumor development |
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deacetylates alpha-tubulin, and thereby destabilizes microtubules |
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HDAC6 inhibition antagonizes thrombin-induced microtubule disassembly |
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possible role for HDAC6 in diverse preclinical models of endothelial barrier dysfunction and the molecular mechanisms that are involved in HDAC6-mediated endothelial barrier dysfunction |
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its function requires the catalytic activity but is independent of ubiquitin binding and deacetylation of alpha-tubulin |
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necessary for angiogenesis, involving the interaction and deacetylation of cortactin that regulates endothelial cells (ECs) migration and sprouting |
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important role of a novel signalling pathway mediated by PRKCA-HDAC6-CTNNB1 in controlling IRF3-mediated transcription |
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essential regulator of hepatic glucocorticoid-stimulated gluconeogenesis and impairment of whole-body glucose metabolism through modification of glucocorticoid receptor nuclear translocation |
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deacetylates survivin to regulate its nuclear export, a feature that may provide a novel target for patients with ER+ breast cancer |
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controls the kinetics of platelet activation |
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balance of acetylation and deaceylation by ATAT1/HDAC6 enzymes with opposite activities regulates the migratory and invasive capacities of breast tumor cells |
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inhibition of its activity accelerated the trafficking of EGFR from early endosomes to late endosomes along the microtubules |
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regulates epidermal growth factor receptor (EGFR) endocytic trafficking and degradation in renal epithelial cells |
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multifunctional cytoplasmic protein that plays an especially critical role in the formation of aggresomes, where aggregates of excess protein are deposited |
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novel modulator of hypoxia-induced invadopodia formation |
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key participant of hypoxia-induced cell invasion |
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tubulin deacetylase that regulates protein aggregation and turnover |
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plays an important role in the regulation of mutant SOD1 aggregation |
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role for HDAC6 in regulating gene expression during transitions between epithelial and mesenchymal phenotypes |
