| 1 | HDAC6, RNF220
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| RNF220-mediated ubiquitination promotes aggresomal accumulation and autophagic degradation of cytoplasmic Gli via HDAC6
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| Wang H, Yang C, Li Y, Zhao S, Ma P, Mao B.
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| Biochem Biophys Res Commun. Jun 11;557:323-328. doi: 10.1016/j.bbrc.2021.03.156. Epub 2021 Apr 22. 2021
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| 2 | HDAC6, MAP3K4
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| MAP3K4 Controls the Chromatin Modifier HDAC6 during Trophoblast Stem Cell Epithelial-to-Mesenchymal Transition.
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| Mobley RJ, Raghu D, Duke LD, Abell-Hart K, Zawistowski JS, Lutz K, Gomez SM, Roy S, Homayouni R, Johnson GL, Abell AN.
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| Cell Rep 18(10):2387-2400. doi: 10.1016/j.celrep.2017.02.030.
2017
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| 3 | HDAC6, PLIN2
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| HDAC6 Suppresses Age-Dependent Ectopic Fat Accumulation by Maintaining the Proteostasis of PLIN2 in Drosophila.
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| Yan Y, Wang H, Hu M, Jiang L, Wang Y, Liu P, Liang X, Liu J, Li C, Lindström-Battle A, Lam SM, Shui G, Deng WM, Jiao R.
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| Dev Cell 43(1):99-111.e5. doi: 10.1016/j.devcel.2017.09.001. Epub 2017 Sep 28.
2017
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| 4 | GID8, HDAC6, MAEA, RANBP9
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| Inhibition of HDAC6 activity through interaction with RanBPM and its associated CTLH complex.
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| Salemi LM, Maitland MER, Yefet ER, Schild-Poulter C.
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| BMC Cancer Jul 1;17(1):460. doi: 10.1186/s12885-017-3430-2. 2017
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| 5 | CCDC141, HDAC6
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| Rescue of CAMDI deletion-induced delayed radial migration and psychiatric behaviors by HDAC6 inhibitor
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| Fukuda T, Nagashima S, Abe T, Kiyonari H, Inatome R, Yanagi S.
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| EMBO Rep. Dec;17(12):1785-1798. doi: 10.15252/embr.201642416. Epub 2016 Oct 13. 2016
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| 6 | HDAC1, HDAC2, HDAC5, HDAC6, HDAC7
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| Quantification of histone deacetylase isoforms in human frontal cortex, human retina, and mouse brain.
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| Anderson KW, Chen J, Wang M, Mast N, Pikuleva IA, Turko IV.
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| PLoS One 10(5):e0126592. doi: 10.1371/journal.pone.0126592. eCollection 2015.
2015
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| 7 | HDAC6, MARCH5, MFN2
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| HDAC6 maintains mitochondrial connectivity under hypoxic stress by suppressing MARCH5/MITOL dependent MFN2 degradation.
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| Kim HJ, Nagano Y, Choi SJ, Park SY, Kim H, Yao TP, Lee JY.
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| Biochem Biophys Res Commun 464(4):1235-1240. doi: 10.1016/j.bbrc.2015.07.111. Epub 2015 Jul 23.
2015
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| 8 | HDAC6, RANBP9
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| Aggresome formation is regulated by RanBPM through an interaction with HDAC6.
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| Salemi LM, Almawi AW, Lefebvre KJ, Schild-Poulter C.
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| Biol Open 3(6):418-30. doi: 10.1242/bio.20147021.
2014
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| 9 | EP300, HDAC6, KAT2B, TRIM50
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| HDAC6 mediates the acetylation of TRIM50.
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| Fusco C, Micale L, Augello B, Mandriani B, Pellico MT, De Nittis P, Calcagně A, Monti M, Cozzolino F, Pucci P, Merla G.
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| Cell Signal 26(2):363-9. doi: 10.1016/j.cellsig.2013.11.036.
2014
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| 10 | DYSF, HDAC6, RIPOR2
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| Fam65b is important for formation of the HDAC6-dysferlin protein complex during myogenic cell differentiation
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| Balasubramanian A, Kawahara G, Gupta VA, Rozkalne A, Beauvais A, Kunkel LM, Gussoni E.
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| FASEB J. Jul;28(7):2955-69. doi: 10.1096/fj.13-246470. Epub 2014 Mar 31. 2014
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| 11 | HDAC6, SEPTIN7
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| Septins promote dendrite and axon development by negatively regulating microtubule stability via HDAC6-mediated deacetylation.
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| Ageta-Ishihara N, Miyata T, Ohshima C, Watanabe M, Sato Y, Hamamura Y, Higashiyama T, Mazitschek R, Bito H, Kinoshita M.
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| Nat Commun 4:2532. doi: 10.1038/ncomms3532. 2013
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| 12 | HDAC6, SOD1
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| HDAC6 regulates mutant SOD1 aggregation through two SMIR motifs and tubulin acetylation.
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| Gal J, Chen J, Barnett KR, Yang L, Brumley E, Zhu H.
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| J Biol Chem 288(21):15035-45. doi: 10.1074/jbc.M112.431957. Epub 2013 Apr 11.
2013
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| 13 | HDAC6
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| HDAC6 deacetylase activity is required for hypoxia-induced invadopodia formation and cell invasion.
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| Arsenault D, Brochu-Gaudreau K, Charbonneau M, Dubois CM.
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| PLoS One 8(2):e55529. doi: 10.1371/journal.pone.0055529. Epub 2013 Feb 6.
2013
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| 14 | HDAC6
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| HDAC6 inhibition restores ciliary expression and decreases tumor growth.
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| Gradilone SA, Radtke BN, Bogert PS, Huang BQ, Gajdos GB, LaRusso NF.
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| Cancer Res 73(7):2259-70. doi: 10.1158/0008-5472.CAN-12-2938. Epub 2013 Jan 31.
2013
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| 15 | HDAC6
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| Histone deacetylase 6 plays a role as a distinct regulator of diverse cellular processes.
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| Li Y, Shin D, Kwon SH.
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| FEBS J 280(3):775-93. doi: 10.1111/febs.12079. Epub 2012 Dec 20. Review.
2013
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| 16 | HDAC6
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| Brain expression level and activity of HDAC6 protein in neurodegenerative dementia.
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| Odagiri S, Tanji K, Mori F, Miki Y, Kakita A, Takahashi H, Wakabayashi K.
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| Biochem Biophys Res Commun 430(1):394-9. doi: 10.1016/j.bbrc.2012.11.034. Epub 2012 Nov 15.
2013
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| 17 | HDAC6
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| The role of HDAC6 in Alzheimer's disease.
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| Zhang L, Sheng S, Qin C.
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| J Alzheimers Dis 33(2):283-95. doi: 10.3233/JAD-2012-120727. Review.
2013
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| 18 | EP400, HDAC6, KAT5
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| Hdac6 regulates Tip60-p400 function in stem cells.
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| Chen PB, Hung JH, Hickman TL, Coles AH, Carey JF, Weng Z, Chu F, Fazzio TG.
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| Elife 2:e01557. doi: 10.7554/eLife.01557.
2013
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| 19 | HDAC6, PRKN, TARDBP
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| Parkin ubiquitinates Tar-DNA binding protein-43 (TDP-43) and promotes its cytosolic accumulation via interaction with histone deacetylase 6 (HDAC6).
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| Hebron ML, Lonskaya I, Sharpe K, Weerasinghe PP, Algarzae NK, Shekoyan AR, Moussa CE.
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| J Biol Chem 288(6):4103-15. doi: 10.1074/jbc.M112.419945. Epub 2012 Dec 20. 2013
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| 20 | HDAC6
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| HDAC6 controls the kinetics of platelet activation.
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| Sadoul K, Wang J, Diagouraga B, Vitte AL, Buchou T, Rossini T, Polack B, Xi X, Matthias P, Khochbin S.
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| Blood 120(20):4215-8. doi: 10.1182/blood-2012-05-428011. Epub 2012 Sep 6.
2012
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| 21 | HDAC6
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| Modulation of histone deacetylase 6 (HDAC6) nuclear import and tubulin deacetylase activity through acetylation.
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| Liu Y, Peng L, Seto E, Huang S, Qiu Y.
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| J Biol Chem 287(34):29168-74. doi: 10.1074/jbc.M112.371120. Epub 2012 Jul 9.
2012
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| 22 | HDAC6
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| Histone deacetylase 6 (HDAC6) is an essential modifier of glucocorticoid-induced hepatic gluconeogenesis.
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| Winkler R, Benz V, Clemenz M, Bloch M, Foryst-Ludwig A, Wardat S, Witte N, Trappiel M, Namsolleck P, Mai K, Spranger J, Matthias G, Roloff T, Truee O, Kappert K, Schupp M, Matthias P, Kintscher U.
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| Diabetes 61(2):513-23. doi: 10.2337/db11-0313. Epub 2011 Dec 30.
2012
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| 23 | EGFR, HDAC6
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| HDAC6 regulates epidermal growth factor receptor (EGFR) endocytic trafficking and degradation in renal epithelial cells.
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| Liu W, Fan LX, Zhou X, Sweeney WE Jr, Avner ED, Li X.
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| PLoS One 7(11):e49418. doi: 10.1371/journal.pone.0049418. Epub 2012 Nov 13.
2012
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| 24 | HDAC6
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| Histone deacetylase 6 (HDAC6) deacetylates survivin for its nuclear export in breast cancer.
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| Riolo MT, Cooper ZA, Holloway MP, Cheng Y, Bianchi C, Yakirevich E, Ma L, Chin YE, Altura RA.
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| J Biol Chem 287(14):10885-93. doi: 10.1074/jbc.M111.308791. Epub 2012 Feb 9.
2012
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| 25 | ATAT1, HDAC6
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| ATAT1/MEC-17 acetyltransferase and HDAC6 deacetylase control a balance of acetylation of alpha-tubulin and cortactin and regulate MT1-MMP trafficking and breast tumor cell invasion.
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| Castro-Castro A, Janke C, Montagnac G, Paul-Gilloteaux P, Chavrier P.
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| Eur J Cell Biol 91(11-12):950-60. doi: 10.1016/j.ejcb.2012.07.001. Epub 2012 Aug 16.
2012
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| 26 | HDAC6, STUB1
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| Loss of HDAC6, a novel CHIP substrate, alleviates abnormal tau accumulation.
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| Cook C, Gendron TF, Scheffel K, Carlomagno Y, Dunmore J, DeTure M, Petrucelli L.
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| Hum Mol Genet 21(13):2936-45. doi: 10.1093/hmg/dds125. Epub 2012 Apr 5.
2012
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| 27 | HDAC6, HMOX1
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| Histone deacetylase 6 (HDAC6) plays a crucial role in p38MAPK-dependent induction of heme oxygenase-1 (HO-1) in response to proteasome inhibition.
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| Kästle M, Woschee E, Grune T.
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| Free Radic Biol Med 53(11):2092-101. doi: 10.1016/j.freeradbiomed.2012.09.023. Epub 2012 Sep 23.
2012
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| 28 | ATF3, HDAC3, HDAC6, JDP2
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| The bZIP repressor proteins, c-Jun dimerization protein 2 and activating transcription factor 3, recruit multiple HDAC members to the ATF3 promoter.
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| Darlyuk-Saadon I, Weidenfeld-Baranboim K, Yokoyama KK, Hai T, Aronheim A.
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| Biochim Biophys Acta 1819(11-12):1142-53. doi: 10.1016/j.bbagrm.2012.09.005. Epub 2012 Sep 16.
2012
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| 29 | HDAC6
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| Pharmacological inhibition of HDAC6 attenuates endothelial barrier dysfunction induced by thrombin.
|
| Saito S, Lasky JA, Guo W, Nguyen H, Mai A, Danchuk S, Sullivan DE, Shan B.
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| Biochem Biophys Res Commun 408(4):630-4. Epub 2011 Apr 21.
2011
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| 30 | CMT2F, HDAC6, HSPB1
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| HDAC6 inhibitors reverse axonal loss in a mouse model of mutant HSPB1-induced Charcot-Marie-Tooth disease.
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| d'Ydewalle C, Krishnan J, Chiheb DM, Van Damme P, Irobi J, Kozikowski AP, Vanden Berghe P, Timmerman V, Robberecht W, Van Den Bosch L.
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| Nat Med 17(8):968-74. doi: 10.1038/nm.2396.
2011
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| 31 | HDAC6
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| Class IIb HDAC6 regulates endothelial cell migration and angiogenesis by deacetylation of cortactin.
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| Kaluza D, Kroll J, Gesierich S, Yao TP, Boon RA, Hergenreider E, Tjwa M, Rössig L, Seto E, Augustin HG, Zeiher AM, Dimmeler S, Urbich C.
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| EMBO J 30(20):4142-56. doi: 10.1038/emboj.2011.298.
2011
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| 32 | HDAC2, HDAC6, SMN2
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| Differential regulation of the SMN2 gene by individual HDAC proteins.
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| Evans MC, Cherry JJ, Androphy EJ.
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| Biochem Biophys Res Commun 414(1):25-30. Epub 2011 Sep 6.
2011
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| 33 | CTNNB1, HDAC6, PRKCA
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| PKC alpha regulates Sendai virus-mediated interferon induction through HDAC6 and β-catenin.
|
| Zhu J, Coyne CB, Sarkar SN.
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| EMBO J 30(23):4838-49. doi: 10.1038/emboj.2011.351.
2011
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| 34 | DYSF, HDAC6
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| Dysferlin interacts with histone deacetylase 6 and increases alpha-tubulin acetylation.
|
| Di Fulvio S, Azakir BA, Therrien C, Sinnreich M.
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| PLoS One 6(12):e28563. doi: 10.1371/journal.pone.0028563. Epub 2011 Dec 8.
2011
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| 35 | CYLD, HDAC6
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| CYLD negatively regulates cell-cycle progression by inactivating HDAC6 and increasing the levels of acetylated tubulin.
|
| Wickström SA, Masoumi KC, Khochbin S, Fässler R, Massoumi R.
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| EMBO J 29(1):131-44. Epub 2009 Nov 5.PMID: 19893491 2010
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| 36 | HDAC6
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| Requirement of a novel splicing variant of human histone deacetylase 6 for TGF-beta1-mediated gene activation.
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| Zhuang Y, Nguyen HT, Lasky JA, Cao S, Li C, Hu J, Guo X, Burow ME, Shan B.
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| Biochem Biophys Res Commun 392(4):608-13. Epub 2010 Jan 25.PMID: 20102703 2010
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| 37 | EGFR, HDAC6
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| The microtubule-associated histone deacetylase 6 (HDAC6) regulates epidermal growth factor receptor (EGFR) endocytic trafficking and degradation.
|
| Gao YS, Hubbert CC, Yao TP.
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| J Biol Chem 285(15):11219-26. Epub 2010 Feb 4.
2010
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| 38 | CDRHX, HDAC6
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| A mutation in the 3'-UTR of the HDAC6 gene abolishing the post-transcriptional regulation mediated by hsa-miR-433 is linked to a new form of dominant X-linked chondrodysplasia.
|
| Simon D, Laloo B, Barillot M, Barnetche T, Blanchard C, Rooryck C, Marche M, Burgelin I, Coupry I, Chassaing N, Gilbert-Dussardier B, Lacombe D, Grosset C, Arveiler B.
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| Hum Mol Genet 19(10):2015-27. Epub 2010 Feb 24. 2010
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| 39 | HDAC6, TPPP
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| TPPP/p25 promotes tubulin acetylation by inhibiting histone deacetylase 6.
|
| Tokési N, Lehotzky A, Horváth I, Szabó B, Oláh J, Lau P, Ovádi J.
|
| J Biol Chem 285(23):17896-906. Epub 2010 Mar 22.PMID: 20308065 2010
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| 40 | FUS, HDAC6, TARDBP
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| Amyotrophic lateral sclerosis-associated proteins TDP-43 and FUS/TLS function in a common biochemical complex to co-regulate HDAC6 mRNA.
|
| Kim SH, Shanware NP, Bowler MJ, Tibbetts RS.
|
| J Biol Chem 285(44):34097-105. Epub 2010 Aug 18.
2010
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| 41 | BRAP, HDAC6, USP16
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| HDAC6 and Ubp-M BUZ domains recognize specific C-terminal sequences of proteins.
|
| Hard RL, Liu J, Shen J, Zhou P, Pei D.
|
| Biochemistry 49(50):10737-46. Epub 2010 Nov 29.
2010
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| 42 | CDC20, HDAC6
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| A centrosomal Cdc20-APC pathway controls dendrite morphogenesis in postmitotic neurons.
|
| Kim AH, Puram SV, Bilimoria PM, Ikeuchi Y, Keough S, Wong M, Rowitch D, Bonni A.
|
| Cell 136(2):322-36.
2009
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| 43 | FNTA, FNTB, HDAC6
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| The protein farnesyltransferase regulates HDAC6 activity in a microtubule-dependent manner.
|
| Zhou J, Vos CC, Gjyrezi A, Yoshida M, Khuri FR, Tamanoi F, Giannakakou P.
|
| J Biol Chem 284(15):9648-55. Epub 2009 Feb 18. 2009
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| 44 | EP300, HDAC6
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| Acetylation of histone deacetylase 6 by p300 attenuates its deacetylase activity.
|
| Han Y, Jeong HM, Jin YH, Kim YJ, Jeong HG, Yeo CY, Lee KY.
|
| Biochem Biophys Res Commun 383(1):88-92. Epub 2009 Apr 1.
2009
|
| 45 | HDAC6
|
| HDAC6 is a target for protection and regeneration following injury in the nervous system.
|
| Rivieccio MA, Brochier C, Willis DE, Walker BA, D'Annibale MA, McLaughlin K, Siddiq A, Kozikowski AP, Jaffrey SR, Twiss JL, Ratan RR, Langley B.
|
| Proc Natl Acad Sci U S A 106(46):19599-604. Epub 2009 Nov 2.PMID: 19884510 2009
|
| 46 | HDAC6, LCOR
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| Function of histone deacetylase 6 as a cofactor of nuclear receptor coregulator LCoR.
|
| Palijan A, Fernandes I, Bastien Y, Tang L, Verway M, Kourelis M, Tavera-Mendoza LE, Li Z, Bourdeau V, Mader S, Yang XJ, White JH.
|
| J Biol Chem 284(44):30264-74. doi: 10.1074/jbc.M109.045526. Epub 2009 Sep 10.
2009
|
| 47 | HDAC1, HDAC10, HDAC11, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7, HDAC8, HDAC9
|
| The Rpd3/Hda1 family of lysine deacetylases: from bacteria and yeast to mice and men.
|
| Yang XJ, Seto E.
|
| Nat Rev Mol Cell Biol 9(3):206-18. Review.
2008
|
| 48 | HDAC6, PRDX1, PRDX2
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| HDAC6 is a specific deacetylase of peroxiredoxins and is involved in redox regulation.
|
| Parmigiani RB, Xu WS, Venta-Perez G, Erdjument-Bromage H, Yaneva M, Tempst P, Marks PA.
|
| Proc Natl Acad Sci U S A 105(28):9633-8. Epub 2008 Jul 7. 2008
|
| 49 | HDAC6
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| HDAC6: a key regulator of cytoskeleton, cell migration and cell-cell interactions.
|
| Valenzuela-Fernández A, Cabrero JR, Serrador JM, Sánchez-Madrid F.
|
| Trends Cell Biol 18(6):291-7. Epub 2008 May 9. Review.
2008
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| 50 | HDAC6, UBD
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| The ubiquitin-like modifier FAT10 interacts with HDAC6 and localizes to aggresomes under proteasome inhibition.
|
| Kalveram B, Schmidtke G, Groettrup M.
|
| J Cell Sci 121(Pt 24):4079-88. Epub 2008 Nov 25.
2008
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| 51 | HDAC6
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| HDAC6 deacetylation of tubulin modulates dynamics of cellular adhesions.
|
| Tran AD, Marmo TP, Salam AA, Che S, Finkelstein E, Kabarriti R, Xenias HS, Mazitschek R, Hubbert C, Kawaguchi Y, Sheetz MP, Yao TP, Bulinski JC.
|
| J Cell Sci 120(Pt 8):1469-79. Epub 2007 Mar 27.
2007
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| 52 | CTTN, HDAC6
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| HDAC6 modulates cell motility by altering the acetylation level of cortactin.
|
| Zhang X, Yuan Z, Zhang Y, Yong S, Salas-Burgos A, Koomen J, Olashaw N, Parsons JT, Yang XJ, Dent SR, Yao TP, Lane WS, Seto E.
|
| Mol Cell 27(2):197-213.
2007
|
| 53 | G3BP1, HDAC6
|
| The deacetylase HDAC6 is a novel critical component of stress granules involved in the stress response.
|
| Kwon S, Zhang Y, Matthias P.
|
| Genes Dev 21(24):3381-94.PMID: 18079183 2007
|
| 54 | HDAC6
|
| Significance of HDAC6 regulation via estrogen signaling for cell motility and prognosis in estrogen receptor-positive breast cancer.
|
| Saji S, Kawakami M, Hayashi S, Yoshida N, Hirose M, Horiguchi S, Itoh A, Funata N, Schreiber SL, Yoshida M, Toi M.
|
| Oncogene 24(28):4531-9. 2005
|
| 55 | HDAC6
|
| The deacetylase HDAC6 regulates aggresome formation and cell viability in response to misfolded protein stress.
|
| Kawaguchi Y, Kovacs JJ, McLaurin A, Vance JM, Ito A, Yao TP.
|
| Cell 115(6):727-38. 2003
|
| 56 | HDAC6
|
| HDAC6 is a microtubule-associated deacetylase.
|
| Hubbert C, Guardiola A, Shao R, Kawaguchi Y, Ito A, Nixon A, Yoshida M, Wang XF, Yao TP.
|
| Nature 417(6887):455-8. 2002
|
| 57 | HDAC6
|
| Assignment of the human histone deacetylase 6 gene (HDAC6) to X chromosome p11.23 by in situ hybridization.
|
| Mahlknecht U, Schnittger S, Landgraf F, Schoch C, Ottmann OG, Hiddemann W, Hoelzer D.
|
| Cytogenet Cell Genet 93(1-2):135-6. No abstract available.
2001
|
| 58 | HDAC4, HDAC5, HDAC6
|
| Three proteins define a class of human histone deacetylases related to yeast Hda1p.
|
| Grozinger CM, Hassig CA, Schreiber SL.
|
| Proc Natl Acad Sci U S A 96(9):4868-73. 1999
|