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FLASH GENE
Symbol SMG6 contributors: mct - updated : 17-01-2024
HGNC name Smg-6 homolog, nonsense mediated mRNA decay factor (C. elegans)
HGNC id 17809
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a C-terminal PIN domain (Glavan 2006)
    • HOMOLOGY
    interspecies homolog to murine Smg6 (90.9pc)
    homolog to Rattus Smg6 (91.4pc)
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • promoting endonucleolytic cleavage of non-sense mRNA (Eberle 2009)
  • molecular link between telomeric repeat-containing RNA regulation and the maintenance of telomere integrity (Azzalin 2007)
  • SMG5-SMG7 and SMG6 exhibit different and non-overlapping modes of UPF1 recognition, thus pointing at distinguished roles in integrating the complex NMD interaction network
  • degradation of NMD target mRNAs involves both exonucleolytic and endonucleolytic pathways in mammalian cells, and the latter is mediated by the endonuclease SMG6
  • loss of the first SMG5-SMG7-dependent pathway also inactivates the second SMG6-dependent branch, indicating an unexpected functional connection between the final NMD steps
  • is an endonuclease, which cleaves mRNAs during nonsense-mediated mRNA decay (NMD), thereby regulating gene expression and controling mRNA quality
  • is a differentiation license factor of totipotent embryonic stem cells
  • SMG6 is an essential regulator of the male germline transcriptome
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA telomeric DNA binding
    RNA
    small molecule metal binding,
  • ions Mn2+ binding
    • protein
  • associated with most or all active telomerase and is involved either directly or indirectly in telomere elongation and telomere capping (Takeshita 2006)
  • physically interacting with the chromosome end replication enzyme telomerase (Redon, 2007)
  • endonuclease SMG6, which cleaves mRNA near the premature translation-termination codons (PTCs), is one of the three known NMD factors thought to be recruited to nonsense mRNAs via an interaction with P-UPF1, leading to eventual mRNA degradation
  • DLX1 and DLX2 were reduced after SMG6 deletion
    • cell & other
  • interacts directly with the EJC (exon junction complex ) via two conserved EJC-binding motifs (
    • REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS