| basic FUNCTION
| inhibitor of NFKB activation |
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negatively modulates ETS1 transcriptional activity and attenuates synergistic transactivation by ETS1 and AP-1 |
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ETS1 modulator that regulates specific aspects of the ETS1 functions |
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may be possessing an antiviral activity like other PML NBs-associated proteins |
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might play an important role in PML NBs-mediated antiviral activity |
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promyelocytic leukemia protein nuclear bodies-associated protein  |
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is the major 5prime-tyrosyl DNA phosphodiesterase activity in vertebrate cells and is critical for cellular resistance to TOP2A-induced DNA damage |
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is a multifunctional protein that can act in the nucleus as a 5'-tyrosyl DNA phosphodiesterase and in the cytoplasm as a regulator of cell signaling |
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function for TDP2 and nucleolar cavities in ribosome biogenesis under stress |
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adaptor molecule that is a novel component of the non-canonical TGFB1 pathway |
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TDP2 contributes to cellular 3prime-TDP activity in the absence of TDP1 |
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TDP1 and TDP2 fulfil overlapping roles following TOP1-induced DNA damage, but not following TOP2A-induced DNA damage |
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is not only specific but also efficient in recognizing and processing trapped TOP2A cleavage complexes even in the form of a longer peptide |
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having preferential action at abortive TOP2A and possibly TOP3A cleavage complexes |
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multi-functional protein that is involved in multiple aspects of cellular functions including cell proliferation, apoptosis and the repair of DNA damage |
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is essential for the life cycle of picornaviruses (important human and bovine pathogens)and is involved in signal transduction |
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repair function of TDP2 is devoted to the excision of topoisomerase II- and potentially topoisomerases III-DNA adducts |
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latest identified cytosolic protein that serves as a negative regulator for TNF signaling pathway |
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is a critical factor in grouper immune response to virus infection |
