| 1 | MAPK6, TDP2, TOP2A
|
| ERK3 regulates TDP2-mediated DNA damage response and chemoresistance in lung cancer cells.
|
| Bian K, Muppani NR, Elkhadragy L, Wang W, Zhang C, Chen T, Jung S, Seternes OM, Long W.
|
| Oncotarget 7(6):6665-75. doi: 10.18632/oncotarget.6682.
2016
|
| 2 | TDP2
|
| TTRAP is a critical factor in grouper immune response to virus infection.
|
| Wei J, Zhang P, Guo M, Xu M, Li P, Chen X, Gao P, Yan Y, Wei S, Qin Q.
|
| Fish Shellfish Immunol 46(2):274-84. doi: 10.1016/j.fsi.2015.07.006. Epub 2015 Jul 11.
2015
|
| 3 | TDP1, TDP2, TOP1, TOP1MT
|
| Tyrosyl-DNA-phosphodiesterases (TDP1 and TDP2).
|
| Pommier Y, Huang SY, Gao R, Das BB, Murai J, Marchand C.
|
| DNA Repair (Amst) 19:114-29. doi: 10.1016/j.dnarep.2014.03.020. Epub 2014 May 22. Review.
2014
|
| 4 | SCAR23, TDP2
|
| TDP2 protects transcription from abortive topoisomerase activity and is required for normal neural function.
|
| Gómez-Herreros F, Schuurs-Hoeijmakers JH, McCormack M, Greally MT, Rulten S, Romero-Granados R, Counihan TJ, Chaila E, Conroy J, Ennis S, Delanty N, Cortés-Ledesma F, de Brouwer AP, Cavalleri GL, El-Khamisy SF, de Vries BB, Caldecott KW.
|
| Nat Genet 46(5):516-21. doi: 10.1038/ng.2929. Epub 2014 Mar 23.
2014
|
| 5 | TDP2
|
| Overexpression of TTRAP inhibits cell growth and induces apoptosis in osteosarcoma cells.
|
| Zhou C, Shen Q, Xue J, Ji C, Chen J.
|
| BMB Rep 46(2):113-8.
2013
|
| 6 | TDP2, TOP2A, TOP3A
|
| Biochemical characterization of human tyrosyl-DNA phosphodiesterase 2 (TDP2/TTRAP): a Mg(2+)/Mn(2+)-dependent phosphodiesterase specific for the repair of topoisomerase cleavage complexes.
|
| Gao R, Huang SY, Marchand C, Pommier Y.
|
| J Biol Chem 287(36):30842-52. doi: 10.1074/jbc.M112.393983. Epub 2012 Jul 20.
2012
|
| 7 | TDP1, TDP2
|
| TDP2 promotes repair of topoisomerase I-mediated DNA damage in the absence of TDP1.
|
| Zeng Z, Sharma A, Ju L, Murai J, Umans L, Vermeire L, Pommier Y, Takeda S, Huylebroeck D, Caldecott KW, El-Khamisy SF.
|
| Nucleic Acids Res 40(17):8371-80. Epub 2012 Jun 26.
2012
|
| 8 | TDP2
|
| The PML nuclear bodies-associated protein TTRAP regulates ribosome biogenesis in nucleolar cavities upon proteasome inhibition.
|
| Vilotti S, Biagioli M, Foti R, Dal Ferro M, Lavina ZS, Collavin L, Del Sal G, Zucchelli S, Gustincich S.
|
| Cell Death Differ 19(3):488-500. doi: 10.1038/cdd.2011.118. Epub 2011 Sep 16.
2012
|
| 9 | TDP2
|
| TTRAP is a novel component of the non-canonical TRAF6-TAK1 TGF-β signaling pathway.
|
| Várady G, Sarkadi B, Fátyol K.
|
| PLoS One 6(9):e25548. doi: 10.1371/journal.pone.0025548. Epub 2011 Sep 27.
2011
|
| 10 | TDP2
|
| TDP2/TTRAP is the major 5'-tyrosyl DNA phosphodiesterase activity in vertebrate cells and is critical for cellular resistance to topoisomerase II-induced DNA damage.
|
| Zeng Z, Cortés-Ledesma F, El Khamisy SF, Caldecott KW.
|
| J Biol Chem 286(1):403-9. doi: 10.1074/jbc.M110.181016. Epub 2010 Oct 28.
2011
|
| 11 | TDP2
|
| Cellular protein TTRAP interacts with HIV-1 integrase to facilitate viral integration.
|
| Zhang JQ, Wang JJ, Li WJ, Huang L, Tian L, Xue JL, Chen JZ, Jia W.
|
| Biochem Biophys Res Commun 387(2):256-60. Epub 2009 Jul 4. 2009
|
| 12 | TDP2
|
| Cellular protein TTRAP interacts with HIV-1 integrase to facilitate viral integration.
|
| Zhang JQ, Wang JJ, Li WJ, Huang L, Tian L, Xue JL, Chen JZ, Jia W.
|
| Biochem Biophys Res Commun 387(2):256-60. doi: 10.1016/j.bbrc.2009.06.153. Epub 2009 Jul 4.
2009
|
| 13 | TDP2
|
| TTRAP is a novel PML nuclear bodies-associated protein.
|
| Xu GL, Pan YK, Wang BY, Huang L, Tian L, Xue JL, Chen JZ, Jia W.
|
| Biochem Biophys Res Commun 375(3):395-8. Epub 2008 Aug 14. 2008
|
| 14 | ETS1, ETS2, TDP2
|
| EAPII interacts with ETS1 and modulates its transcriptional function.
|
| Pei H, Yordy JS, Leng Q, Zhao Q, Watson DK, Li R.
|
| Oncogene 22(18):2699-709. 2003
|
| 15 | TDP2
|
| TTRAP, a novel protein that associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor-associated factors (TRAFs), and that inhibits nuclear factor-kappa B activation.
|
| Pype S, Declercq W, Ibrahimi A, Michiels C, Van Rietschoten JG, Dewulf N, de Boer M, Vandenabeele P, Huylebroeck D, Remacle JE.
|
| J Biol Chem 275(24):18586-93. 2000
|