| basic FUNCTION
| mediating repression by the Mad-Max complex |
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transcriptional role for SIN3A and SIN3B proteins associated with maintenance of differentiated muscle cells  |
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SIN3A and SIN3B regulate gene expression at the chromatin-level by serving as an anchor onto which the core SIN3/HDAC complex is assembled |
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is an important mediator of the STAT3-targeted transcriptional repression |
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critical role for the SIN3A complex in balancing STAT functions at the transcriptional level |
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unique role for the SIN3A complex as a negative regulator of STAT3 transcriptional activity, regardless of the activating stimulus |
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exerting opposite regulation on STAT3 and ISGF3-dependent transcription, SIN3A represents a unique control level determining cytokine-specific responses in different tissues or cells |
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within the male germline, SIN3A is required for the mitotic reentry of gonocytes, but is dispensable for the maintenance of differentiating spermatogonia and subsequent spermatogenic processes |
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is a key buffer controlling muscle responsiveness to transcription factors in the formation of muscle identity, thereby generating tissue diversity |
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metastasis suppressive roles of SIN3A and metastasis promoting roles of SIN3B in breast cancer |
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corepressor SIN3A controls histone acetylation through association with the histone deacetylase RPD3 |
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is an important epigenetic regulator directly connecting methionine metabolism and histone modification |
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SIN3A and SIN3B contribute likely to repressor function of enhancers and promoters in peripheral blood mononuclear cells (PBMCs) |
