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FLASH GENE
Symbol SIN3A contributors: mct/npt/pgu - updated : 01-02-2017
HGNC name SIN3 homolog A, transcriptional regulator (yeast)
HGNC id 19353
Location 15q24.2      Physical location : 75.661.721 - 75.748.124
Synonym name
  • histone deacetylase complex subunit Sin3a
  • transcriptional co-repressor Sin3A
  • paired amphipathic helix protein Sin3a
    • Synonym symbol(s) KIAA0700, DKFZP434K2235, mSIN3A, FLJ90319, SIN3
    DNA
    TYPE functioning gene
    STRUCTURE 86.44 kb     21 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Map see TM6SF1
    RNA
    TRANSCRIPTS type messenger
    text Variants 1, 2 and 3 encode the same protein
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    21 - 6697 145 1273 - 1995 7889570
    21 - 6795 145 1273 - 1995 7889570
    21 - 6620 145 1273 - 1995 7889570
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivemouthtongue  highly
    Lymphoid/Immunethymus   highly
    Reproductivefemale systembreastmammary gland highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES acid Amphiphilic
    STRUCTURE
    motifs/domains
  • four PAH (paired amphipathic helix) motifs, PAH3 interacting with SAP30
  • a poly-proline, a poly-alanine-glutamine and acidic regions
    • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to murine Sin3a
    ortholog to rattus Sin3a predicted
    intraspecies paralog to SIN3B
    Homologene
    FAMILY
    CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome,kinetochore
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • mediating repression by the Mad-Max complex
  • transcriptional role for SIN3A and SIN3B proteins associated with maintenance of differentiated muscle cells
  • SIN3A and SIN3B regulate gene expression at the chromatin-level by serving as an anchor onto which the core SIN3/HDAC complex is assembled
  • is an important mediator of the STAT3-targeted transcriptional repression
  • critical role for the SIN3A complex in balancing STAT functions at the transcriptional level
  • unique role for the SIN3A complex as a negative regulator of STAT3 transcriptional activity, regardless of the activating stimulus
  • exerting opposite regulation on STAT3 and ISGF3-dependent transcription, SIN3A represents a unique control level determining cytokine-specific responses in different tissues or cells
  • within the male germline, SIN3A is required for the mitotic reentry of gonocytes, but is dispensable for the maintenance of differentiating spermatogonia and subsequent spermatogenic processes
  • is a key buffer controlling muscle responsiveness to transcription factors in the formation of muscle identity, thereby generating tissue diversity
  • metastasis suppressive roles of SIN3A and metastasis promoting roles of SIN3B in breast cancer
  • corepressor SIN3A controls histone acetylation through association with the histone deacetylase RPD3
  • is an important epigenetic regulator directly connecting methionine metabolism and histone modification
  • SIN3A and SIN3B contribute likely to repressor function of enhancers and promoters in peripheral blood mononuclear cells (PBMCs)
    • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    text transcription co-repressor
    PATHWAY
    metabolism
    signaling
    a component
  • methylglyoxal modification
  • part of an MORF4L1/PHF12/SIN3A complex may be implicated in the unique functions of MORF4L1
  • SIN3A complex acts as a context-dependent ISGF3/STAT3 transcriptional switch
    • INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • interacting with NFX1 (NFX1-91 interacts with the corepressor complex SIN3A/histone deacetylase (HDAC) at the TERT promoter)
  • ING2 binding to the SIN3A complex may be enhanced by sumoylation of ING2
  • interacting with SAP30 and forming a SIN3A PAH3-SAP30 SID complex that can bind to nucleic acids
  • SIN3A coupled with MECP2 bound to the GFAP promoter and their occupancies were correlated with repression of GFAP transcription
  • FOXK1 interacts with SIN3A/SIN3B through the SID and SIN3A/SIN3B has an important role in the regulation of cell cycle kinetics of the myogenic progenitors cells population
  • directly interacts with STAT3 and promotes its deacetylation
  • FAM60A promotes the retention of HDAC1 but not SIN3A at the CCND1 promoter in asynchronously growing cells
  • PHF12 interacts directly with SIN3A, which in turn interacts with SNAI2, resulting in recruitment of the HDAC complex to the promoter region of CDH6
  • SIN3A-associated HDAC1/2-activity is essential for hematopoietic stem cell homeostasis
  • SIN3A physically interacts with the CYP1A1 gene and extends the transcriptional role of SIN3A to a gene that is very rapidly and dramatically induced
  • catalytic domain of TET3 interacts with HDAC1 and SIN3A, thus enhancing their binding to the IFNB1 promoter
  • TET1 is found to recruit the co-repressor proteins, SIN3A and the histone lysine methyltransferase, EZH2 to osteogenic genes
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS