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FLASH GENE

Symbol

GREM1

contributors: mct/npt/pgu - updated : 27-08-2015

HGNC name	gremlin 1, cysteine knot superfamily, homolog (Xenopus laevis)
HGNC id	2001

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   associated with tumor progression tumoral     --other   aberrantly expressed by cancer-associated stromal cells (basal cell carcinoma) constitutional     --over   overexpression causes osteopenia constitutional   deletion     causes increased trabecular bone volume secondary to increased bone formation and osteoblastic activity constitutional   deletion     has a major impact in the early phases of bone acquisition, and are in accordance with the role of BMPs during skeletal development tumoral     --low   by hypermethylation in renal cell carcinoma constitutional germinal mutation       in isolated Congenital anomalies of the kidney and urinary tract (CAKUT) constitutional     --over   in rheumatoid arthritis (RA) joints

Susceptibility

to colorectal cancer (CRC)

Variant & Polymorphism other	SNPs near GREM1 were strongly associated with increased CRC risk

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed neurosensorial visual anterior chamber modulation of the extracellular matrix via gremlin provides a novel therapeutic target for glaucoma

ANIMAL & CELL MODELS