| 1 | GREM1
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| GREM1 Is a Key Regulator of Synoviocyte Hyperplasia and Invasiveness.
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| Han EJ, Yoo SA, Kim GM, Hwang D, Cho CS, You S, Kim WU.
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| J Rheumatol Rheumatol. 2016 Feb 1. pii: jrheum.150523. [Epub ahead of print]
2016
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| 2 | GREM1, KDR
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| Gremlin regulates renal inflammation via the vascular endothelial growth factor receptor 2 pathway.
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| Lavoz C, Alique M, Rodrigues-Diez R, Pato J, Keri G, Mezzano S, Egido J, Ruiz-Ortega M.
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| J Pathol 236(4):407-20. doi: 10.1002/path.4537. Epub 2015 May 19.
2015
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| 3 | GREM1
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| Gremlin 1 identifies a skeletal stem cell with bone, cartilage, and reticular stromal potential.
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| Worthley DL, Churchill M, Compton JT, Tailor Y, Rao M, Si Y, Levin D, Schwartz MG, Uygur A, Hayakawa Y, Gross S, Renz BW, Setlik W, Martinez AN, Chen X, Nizami S, Lee HG, Kang HP, Caldwell JM, Asfaha S, Westphalen CB, Graham T, Jin G, Nagar K, Wang H, Kheirbek MA, Kolhe A, Carpenter J, Glaire M, Nair A, Renders S, Manieri N, Muthupalani S, Fox JG, Reichert M, Giraud AS, Schwabe RF, Pradere JP, Walton K, Prakash A, Gumucio D, Rustgi AK, Stappenbeck TS, Friedman RA, Gershon MD, Sims P, Grikscheit T, Lee FY, Karsenty G, Mukherjee S, Wang TC.
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| Cell 160(1-2):269-84. doi: 10.1016/j.cell.2014.11.042.
2015
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| 4 | BMP2, GREM1
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| Gremlin1 preferentially binds to bone morphogenetic protein-2 (BMP-2) and BMP-4 over BMP-7.
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| Church RH, Krishnakumar A, Urbanek A, Geschwindner S, Meneely J, Bianchi A, Basta B, Monaghan S, Elliot C, Strömstedt M, Ferguson N, Martin F, Brazil DP.
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| Biochem J 466(1):55-68. doi: 10.1042/BJ20140771.
2015
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| 5 | CTGF, GREM1, TGFB2
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| TGF-β2 induces transdifferentiation and fibrosis in human lens epithelial cells via regulating gremlin and CTGF.
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| Ma B, Kang Q, Qin L, Cui L, Pei C.
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| Biochem Biophys Res Commun 447(4):689-95. doi: 10.1016/j.bbrc.2014.04.068. Epub 2014 Apr 19.
2014
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| 6 | FRAS1, FREM1, FREM2, GREM1, GRIP1, ITGA8
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| Mild recessive mutations in six Fraser syndrome-related genes cause isolated congenital anomalies of the kidney and urinary tract.
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| Kohl S, Hwang DY, Dworschak GC, Hilger AC, Saisawat P, Vivante A, Stajic N, Bogdanovic R, Reutter HM, Kehinde EO, Tasic V, Hildebrandt F.
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| J Am Soc Nephrol 25(9):1917-22. doi: 10.1681/ASN.2013101103. Epub 2014 Apr 3.
2014
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| 7 | GREM1
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| Overexpression of Gremlin-1 in patients with Loeys-Dietz syndrome: implications on pathophysiology and early disease detection.
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| Wellbrock J, Sheikhzadeh S, Oliveira-Ferrer L, Stamm H, Hillebrand M, Keyser B, Klokow M, Vohwinkel G, Bonk V, Otto B, Streichert T, Balabanov S, Hagel C, Rybczynski M, Bentzien F, Bokemeyer C, von Kodolitsch Y, Fiedler W.
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| PLoS One 9(8):e104742. doi: 10.1371/journal.pone.0104742. eCollection 2014.
2014
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| 8 | GREM1
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| Gremlin activates the Smad pathway linked to epithelial mesenchymal transdifferentiation in cultured tubular epithelial cells.
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| Rodrigues-Diez R, Rodrigues-Diez RR, Lavoz C, Carvajal G, Droguett A, Garcia-Redondo AB, Rodriguez I, Ortiz A, Egido J, Mezzano S, Ruiz-Ortega M.
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| Biomed Res Int 2014:802841. doi: 10.1155/2014/802841. Epub 2014 May 18.
2014
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| 9 | GREM1, GREM2, TBX2
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| Tbx2 terminates shh/fgf signaling in the developing mouse limb bud by direct repression of gremlin1.
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| Farin HF, Lüdtke TH, Schmidt MK, Placzko S, Schuster-Gossler K, Petry M, Christoffels VM, Kispert A.
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| PLoS Genet 9(4):e1003467. doi: 10.1371/journal.pgen.1003467. Epub 2013 Apr 25.
2013
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| 10 | GREM1, NOG
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| The expression patterns of gremlin 1 and noggin in normal adult and tumor tissues.
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| Laurila R, Parkkila S, Isola J, Kallioniemi A, Alarmo EL.
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| Int J Clin Exp Pathol 6(7):1400-8. Print 2013.
2013
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| 11 | BMP2, GREM1, GREM2
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| BMP2 differentially regulates the expression of Gremlin1 and Gremlin2, the negative regulators of BMP function, during osteoblast differentiation.
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| Suzuki D, Yamada A, Aizawa R, Funato S, Matsumoto T, Suzuki W, Takami M, Miyamoto Y, Suzawa T, Yamamoto M, Baba K, Kamijo R.
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| Calcif Tissue Int 91(1):88-96. doi: 10.1007/s00223-012-9614-5. Epub 2012 May 29.
2012
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| 12 | GREM1, SHH, TWIST2
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| Twist2 contributes to termination of limb bud outgrowth and patterning through direct regulation of Grem1.
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| Wade C, Brinas I, Welfare M, Wicking C, Farlie PG.
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| Dev Biol 370(1):145-53. doi: 10.1016/j.ydbio.2012.07.025. Epub 2012 Aug 1.
2012
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| 13 | GREM1, NOG
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| Cooperative activity of noggin and gremlin 1 in axial skeleton development.
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| Stafford DA, Brunet LJ, Khokha MK, Economides AN, Harland RM.
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| Development 138(5):1005-14.
2011
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| 14 | GREM1, SIX1
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| Six1 regulates Grem1 expression in the metanephric mesenchyme to initiate branching morphogenesis.
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| Nie X, Xu J, El-Hashash A, Xu PX.
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| Dev Biol 352(1):141-51. Epub 2011 Jan 31.
2011
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| 15 | CTGF, GREM1, TGFB2
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| Role of TGFbeta/Smad signaling in gremlin induction of human trabecular meshwork extracellular matrix proteins.
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| Sethi A, Jain A, Zode GS, Wordinger RJ, Clark AF.
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| Invest Ophthalmol Vis Sci 52(8):5251-9. doi: 10.1167/iovs.11-7587.
2011
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| 16 | BNC1, COL14A1, COL15A1, CST6, GREM1, PDLIM4, RPRM, SFRP1
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| Identification of candidate tumour suppressor genes frequently methylated in renal cell carcinoma.
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| Morris MR, Ricketts C, Gentle D, Abdulrahman M, Clarke N, Brown M, Kishida T, Yao M, Latif F, Maher ER.
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| Oncogene ncogene. 2010 Feb 15. [Epub ahead of print]PMID: 20154727 2010
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| 17 | FMN1, GREM1
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| Formin1 disruption confers oligodactylism and alters Bmp signaling.
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| Zhou F, Leder P, Zuniga A, Dettenhofer M.
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| Hum Mol Genet 18(13):2472-82. Epub 2009 Apr 20.
2009
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| 18 | BMP4, GREM1
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| Bone morphogenetic protein 4 inhibits TGF-beta2 stimulation of extracellular matrix proteins in optic nerve head cells: role of gremlin in ECM modulation.
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| Zode GS, Clark AF, Wordinger RJ.
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| Glia 57(7):755-66.
2009
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| 19 | EFEMP1, GREM1, PRELP
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| Molecular differentiation in epiphyseal and physeal cartilage. Prominent role for gremlin in maintaining hypertrophic chondrocytes in epiphyseal cartilage.
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| Shapiro F, Flynn E, Calicchio ML.
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| Biochem Biophys Res Commun 390(3):570-6. Epub 2009 Oct 8.PMID: 19818739 2009
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| 20 | CRAC1, GREM1, SCG5
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| Common genetic variants at the CRAC1 (HMPS) locus on chromosome 15q13.3 influence colorectal cancer risk.
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| Jaeger E, Webb E, Howarth K, Carvajal-Carmona L, Rowan A, Broderick P, Walther A, Spain S, Pittman A, Kemp Z, Sullivan K, Heinimann K, Lubbe S, Domingo E, Barclay E, Martin L, Gorman M, Chandler I, Vijayakrishnan J, Wood W, Papaemmanuil E, Penegar S, Qureshi M; CORGI Consortium, Farrington S, Tenesa A, Cazier JB, Kerr D, Gray R, Peto J, Dunlop M, Campbell H, Thomas H, Houlston R, Tomlinson I.
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| Nat Genet 40(1):26-8. Epub 2007 Dec 16.
2008
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| 21 | GREM1
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| Gremlin enhances the determined path to cardiomyogenesis.
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| Kami D, Shiojima I, Makino H, Matsumoto K, Takahashi Y, Ishii R, Naito AT, Toyoda M, Saito H, Watanabe M, Komuro I, Umezawa A.
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| PLoS One 3(6):e2407.
2008
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| 22 | GREM1
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| Activation of the ERK pathway in osteoblastic cells, role of gremlin and BMP-2.
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| Zanotti S, Smerdel-Ramoya A, Stadmeyer L, Canalis E.
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| J Cell Biochem 104(4):1421-6.
2008
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| 23 | GREM1
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| The role of gremlin, a BMP antagonist, and epithelial-to-mesenchymal transition in proliferative vitreoretinopathy.
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| Lee H, O'Meara SJ, O'Brien C, Kane R.
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| Invest Ophthalmol Vis Sci 48(9):4291-9. 2007
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| 24 | GREM1
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| Conditional deletion of gremlin causes a transient increase in bone formation and bone mass.
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| Gazzerro E, Smerdel-Ramoya A, Zanotti S, Stadmeyer L, Durant D, Economides AN, Canalis E.
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| J Biol Chem 282(43):31549-57. Epub 2007 Sep 4. 2007
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| 25 | GREM1
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| Expression of gremlin, a bone morphogenetic protein antagonist, in glomerular crescents of pauci-immune glomerulonephritis.
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| Mezzano S, Droguett A, Burgos ME, Aros C, Ardiles L, Flores C, Carpio D, Carvajal G, Ruiz-Ortega M, Egido J.
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| Nephrol Dial Transplant 22(7):1882-90. Epub 2007 Apr 1.
2007
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| 26 | GREM1
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| Bone morphogenetic protein antagonist gremlin 1 is widely expressed by cancer-associated stromal cells and can promote tumor cell proliferation.
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| Sneddon JB, Zhen HH, Montgomery K, van de Rijn M, Tward AD, West R, Gladstone H, Chang HY, Morganroth GS, Oro AE, Brown PO.
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| Proc Natl Acad Sci U S A 103(40):14842-7. Epub 2006 Sep 26. 2006
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| 27 | DAND5, CER1, NODAL, GREM1
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| CER1 is a common target of WNT and NODAL signaling pathways in human embryonic stem cells.
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| Katoh M, Katoh M.
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| Int J Mol Med 17(5):795-9. 2006
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| 28 | BMP4, GREM1
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| Regulation of myogenic progenitor proliferation in human fetal skeletal muscle by BMP4 and its antagonist Gremlin.
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| Frank NY, Kho AT, Schatton T, Murphy GF, Molloy MJ, Zhan Q, Ramoni MF, Frank MH, Kohane IS, Gussoni E.
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| J Cell Biol 175(1):99-110. Epub 2006 Oct 2.
2006
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| 29 | GREM1, YWHAH
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| The bone morphogenetic protein antagonist gremlin 1 is overexpressed in human cancers and interacts with YWHAH protein.
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| Namkoong H, Shin SM, Kim HK, Ha SA, Cho GW, Hur SY, Kim TE, Kim JW.
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| BMC Cancer 6:74.
2006
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| 30 | GREM1
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| Gremlin is the BMP antagonist required for maintenance of Shh and Fgf signals during limb patterning.
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| Khokha MK, Hsu D, Brunet LJ, Dionne MS, Harland RM.
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| Nat Genet 34(3):303-7. 2003
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| 31 | BMP2, BMP4, BMP7, BMPR1A, BMPR1B, BMPR2, GREM1
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| Expression of bone morphogenetic proteins (BMP), BMP receptors, and BMP associated proteins in human trabecular meshwork and optic nerve head cells and tissues.
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| Wordinger RJ, Agarwal R, Talati M, Fuller J, Lambert W, Clark AF.
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| Mol Vis 8:241-50. 2002
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| 32 | GREM1
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| DRM/GREMLIN (CKTSF1B1) maps to human chromosome 15 and is highly expressed in adult and fetal brain.
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| Topol LZ, Modi WS, Koochekpour S, Blair DG.
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| Cytogenet Cell Genet 89(1-2):79-84. 2000
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| 33 | GREM1
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| The Xenopus dorsalizing factor Gremlin identifies a novel family of secreted proteins that antagonize BMP activities.
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| Hsu DR, Economides AN, Wang X, Eimon PM, Harland RM.
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| Mol Cell 1(5):673-83. 1998
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| 34 | GREM1
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| Gazzerro E, Smerdel-Ramoya A, Zanotti S, Stadmeyer L, Durant D, Economides AN, Canalis E.
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| Conditional deletion of gremlin causes a transient increase in bone formation and bone mass onditional deletion of gremlin causes a transient increase in bone formation and bone mass. 0
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