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FLASH GENE

Symbol

SLC27A1

contributors: mct/pgu - updated : 11-01-2017

HGNC name	solute carrier family 27 (fatty acid transporter), member 1
HGNC id	10995

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

MROS2

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   in skeletal muscle increased the rate of SLC27A1 transport and channelled these lipids to oxidation, not to intramuscular lipid accumulation constitutional     --over   upon weight loss in morbidly obese patients

Susceptibility

Variant & Polymorphism SNP	associated with increased plasma triglycerides and alteration in LDL particle distribution

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed diabete     antidiabetic target

ANIMAL & CELL MODELS

skeletal muscle Slc27a1 overabundance does not predispose animals to diet-induced insulin resistance