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FLASH GENE
Symbol SLC27A1 contributors: mct/pgu - updated : 11-01-2017
HGNC name solute carrier family 27 (fatty acid transporter), member 1
HGNC id 10995
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • six membrane-spanning segments
  • three N glycosylation sites
  • a lipocalin motif
  • AMP binding domain
  • HOMOLOGY
    Homologene
    FAMILY
  • ATP-dependent AMP-binding enzyme family
  • CATEGORY enzyme , regulatory , transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    text
  • predominantly cytoplasmic in myocytes
  • some SLC27A1 translocates to the plasma membrane in response to insulin, but the majority remains within intracellular structures and potentially the protein primarily resides in the mitochondrion
  • basic FUNCTION
  • involved in translocation of long-chain fatty acids (lfca) across the plasma membrane
  • enhancing the cellular uptake of long-chain fatty acids
  • may be involved in regulation of cholesterol metabolism
  • having acyl-coa ligase activity for long-chain and very-long-chain fatty acids
  • regulatory function of SLC27A1 in myotube mitochondria
  • is associated with mitochondria and has a role in mitochondrial oxidation of fatty acids
  • insulin-sensitive fatty acid transporter involved in diet-induced obesity
  • role as a regulator of tricarboxylic acid cycle activity and mitochondrial function
  • mediates fatty acid-induced activation of AMPK in adipocytes and provides a potential regulatory mechanism for balancing de novo production of fatty acids from glucose metabolism with influx of preformed fatty acids via phosphorylation of acetyl-CoA carboxylase
  • is a novel regulator of reprogramming of macrophages activation through control of substrate metabolism
  • metabolic reprogramming through SLC27A1 regulates macrophage inflammatory potential and adipose inflammation
  • localized at the basal membrane of brain microvessels contributes to the transport of docosahexaenoic acid (DHA), taurine and biotin into the brain
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS facilitated diffusion transport
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    a component
  • evolutionarily conserved SLC27A1-DGAT2 complex acts at the ER-LD interface and couples the synthesis and deposition of triglycerides into lipid droplets (LDs) both physically and functionally
  • INTERACTION
    DNA
    RNA
    small molecule
  • cAMP
  • protein
  • markedly inhibits 11-cis retinol production by acting on the production of all-trans retinyl esters and the isomerase activity of RPE65
  • NR2C2 transactivated SLC27A1 5prime promoter activity via direct binding to the NR2C2 responsive element located at the SLC27A1 5prime promoter region
  • preferentially associated with DGAT2, and they acted synergistically to promote lipid droplets (LDs) expansion in mammalian cells
  • cell & other
    REGULATION
    activated by PPAR and RXR agonists
    NR2C2 (activates SLC27A1 gene expression to promote lipid accumulation in 3T3-L1 adipocytes)
    ASSOCIATED DISORDERS
    corresponding disease(s) MROS2
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in skeletal muscle increased the rate of SLC27A1 transport and channelled these lipids to oxidation, not to intramuscular lipid accumulation
    constitutional     --over  
    upon weight loss in morbidly obese patients
    Susceptibility
    Variant & Polymorphism SNP associated with increased plasma triglycerides and alteration in LDL particle distribution
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    diabete  
    antidiabetic target
    ANIMAL & CELL MODELS
    skeletal muscle Slc27a1 overabundance does not predispose animals to diet-induced insulin resistance