SUBCELLULAR LOCALIZATION
| plasma membrane
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| intracellular
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| intracellular,cytoplasm,organelle,mitochondria,inner
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| intracellular,cytoplasm,organelle,membrane
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| intracellular,cytoplasm,organelle,endoplasmic reticulum
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| text
| predominantly cytoplasmic in myocytes |
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some SLC27A1 translocates to the plasma membrane in response to insulin, but the majority remains within intracellular structures and potentially the protein primarily resides in the mitochondrion  |
| basic FUNCTION
| involved in translocation of long-chain fatty acids (lfca) across the plasma membrane |
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enhancing the cellular uptake of long-chain fatty acids |
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may be involved in regulation of cholesterol metabolism |
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having acyl-coa ligase activity for long-chain and very-long-chain fatty acids |
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regulatory function of SLC27A1 in myotube mitochondria |
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is associated with mitochondria and has a role in mitochondrial oxidation of fatty acids |
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insulin-sensitive fatty acid transporter involved in diet-induced obesity |
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role as a regulator of tricarboxylic acid cycle activity and mitochondrial function |
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mediates fatty acid-induced activation of AMPK in adipocytes and provides a potential regulatory mechanism for balancing de novo production of fatty acids from glucose metabolism with influx of preformed fatty acids via phosphorylation of acetyl-CoA carboxylase |
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is a novel regulator of reprogramming of macrophages activation through control of substrate metabolism |
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metabolic reprogramming through SLC27A1 regulates macrophage inflammatory potential and adipose inflammation |
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localized at the basal membrane of brain microvessels contributes to the transport of docosahexaenoic acid (DHA), taurine and biotin into the brain |
