| Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
|---|
| tumoral
|
|
|
| loss of function
|
|
by hypermethylation in ovarian carcinoma |
| tumoral
|
| amplification
|
|
|
|
with MET oncogene in gastric cancer |
| constitutional
|
|
| --low
|
|
association between reduced TES expression and coronary artery disease  |
| tumoral
|
| LOH
|
|
|
|
in primary gastric cancer |
| tumoral
|
|
| --low
|
|
|
is the most frequently methylated and silenced gene yet reported in childhood acute lymphoblastic leukaemia |
| constitutional
|
|
| --low
|
|
|
associate with loss by cells epithelial morphology and gain migratory and invasive properties of mesenchymal cells |
| tumoral
|
|
|
| loss of function
|
|
in human endometrial carcinoma |
| tumoral
|
|
| --other
|
|
|
is aberrantly methylated in ALL |
