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FLASH GENE
Symbol KCNS3 contributors: mct - updated : 24-06-2014
HGNC name potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3
HGNC id 6302
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • six putative membrane-spanning domains
  • an hydrophobic pore including the P domain with the K+ channel signature, flanked by TM domains 5 and 6, sensitive to changes in membrane potential
    • mono polymer homomer , dimer
    HOMOLOGY
    Homologene
    FAMILY potassium channel family B,(SHAB) subfamily
    CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • mediating the voltage-dependent potassium ion permeability of excitable membranes
  • assuming opened or closed conformations in response to the voltage difference across the membrane
  • is a selective marker of parvalbumin (PV) neurons
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component heteromultimer with KCNB1 and with KCNB2
    INTERACTION
    DNA
    RNA
    small molecule
    protein KCNB1,KCNB2
    cell & other
    REGULATION
    activated by BMP2 that significantly (>2-fold) upregulated mRNA expression of KCNS3
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to asthma (airway hyperesponsiveness)
    Variant & Polymorphism SNP associated with higher risk of asthma
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS