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FLASH GENE

Symbol

KCNS3

contributors: mct - updated : 24-06-2014

HGNC name	potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3
HGNC id	6302

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver         Lymphoid/Immune lymph node         Nervous brain         Reproductive female system ovary         male system prostate       Respiratory lung         Visual eye lens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	six putative membrane-spanning domains
	an hydrophobic pore including the P domain with the K+ channel signature, flanked by TM domains 5 and 6, sensitive to changes in membrane potential

mono polymer

homomer , dimer

HOMOLOGY

Homologene

FAMILY

potassium channel family B,(SHAB) subfamily

CATEGORY

transport channel

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	mediating the voltage-dependent potassium ion permeability of excitable membranes
	assuming opened or closed conformations in response to the voltage difference across the membrane
	is a selective marker of parvalbumin (PV) neurons

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

heteromultimer with KCNB1 and with KCNB2

INTERACTION

DNA

RNA

small molecule

protein

KCNB1,KCNB2

cell & other

REGULATION

activated by

BMP2 that significantly (>2-fold) upregulated mRNA expression of KCNS3

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

to asthma (airway hyperesponsiveness)

Variant & Polymorphism SNP	associated with higher risk of asthma

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS