| basic FUNCTION
| negative coregulator of LIM homeodomain proteins through recruitement of the SIN3A histone deacetylase complex |
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ubiquitin protein ligase able to target CLIM cofactors for degradation through the 26S proteasome pathway |
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RING H2 zinc finger protein with intrinsic ubiquitin ligase activity, as a TRF1-interacting protein  |
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specific regulator of LDB1 to ensure its proper interactions with LIM-HD proteins and possibly other LDB1-interacting proteins in the organizer as well as in other tissues |
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represents a new pathway for modulating telomere length homeostasis by acting as a negative regulator of TERF1 |
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regulate the biological activity of ESR1 during the development of breast cancer (Johnsen 2009) |
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dose-dependent activator of X-chromosome inactivation |
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indispensable factor in up-regulation of XIST transcription, thereby leading to initiation of random X chromosome inactivation (XCI) |
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enhances transcriptional activation of endogenous estrogen receptor alpha (ESR1) target genes |
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critical for the regulation of X-inactivation, and is negatively regulated by pluripotency factors in embryonic stem cells |
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is an important positive regulator in TGFB signaling pathway and cell migration |
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may play an important role during the development of human cancer |
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may possess similar cellular properties with R-Smads |
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acts at two subsequent steps: two active copies of RNF12 drive initiation of X chromosome inactivation (XCI), and one copy needs to remain active to maintain XCI toward establishment of the inactive X chromosome (Xi) |
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RLIM may function as a tumor suppressor by controlling the activity of MYC oncoprotein |
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RLIM-dependent and -independent pathways for X Chromosome inactivation in female ESCs |
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RLIM catalytic activity is required for proper stem cell maintenance and neural differentiation, and this is disrupted by patient-associated XLID mutation |
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key function for RLIM E3 ubiquitin ligase activity in stem cell and neural development |
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during female embryogenesis, major roles of RLIM have been identified in conjunction with REXO1 during X dosage compensation |
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crucial importance to the RLIM-REXO1 axis in controlling XCI |
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is involved in control of early embryogenesis, notably brain and neural tube development |
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is a dosage-sensitive gene and increased protein levels arising from duplications are associated with neurocognitive abnormalities |
