| 1 | DUPXQ13, FTX, NEXMIF, RLIM, SLC16A2
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| RLIM Is a Candidate Dosage-Sensitive Gene for Individuals with Varying Duplications of Xq13, Intellectual Disability, and Distinct Facial Features
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| Palmer EE, Carroll R, Shaw M, Kumar R, Minoche AE, Leffler M, Murray L, Macintosh R, Wright D, Troedson C, McKenzie F, Townshend S, Ward M, Nawaz U, Ravine A, Runke CK, Thorland EC, Hummel M, Foulds N, Pichon O, Isidor B, Le Caignec C, Demeer B, Andrieux J, Albarazi SH, Bye A, Sachdev R, Kirk EP, Cowley MJ, Field M, Gecz J.
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| Am J Hum Genet. Oct 28:S0002-9297(20)30363-3. doi: 10.1016/j.ajhg.2020.10.005. Epub ahead of print. 2020
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| 2 | DUPXQ13, FTX, NEXMIF, RLIM, SLC16A2
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| RLIM Is a Candidate Dosage-Sensitive Gene for Individuals with Varying Duplications of Xq13, Intellectual Disability, and Distinct Facial Features. 2020 Dec 3;107(6):1157-1169. doi: 10.1016/j.ajhg.2020.10.005. Epub 2020 Nov 6. PMID:
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| Palmer EE, Carroll R, Shaw M, Kumar R, Minoche AE, Leffler M, Murray L, Macintosh R, Wright D, Troedson C, McKenzie F, Townshend S, Ward M, Nawaz U, Ravine A, Runke CK, Thorland EC, Hummel M, Foulds N, Pichon O, Isidor B, Le Caignec C, Demeer B, Andrieux J, Albarazi SH, Bye A, Sachdev R, Kirk EP, Cowley MJ, Field M, Gecz J
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| Am J Hum Genet. Dec 3;107(6):1157-1169. doi: 10.1016/j.ajhg.2020.10.005. Epub 2020 Nov 6. 2020
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| 3 | REXO1, RLIM
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| Rlim/Rnf12, Rex1, and X Chromosome Inactivation
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| Wang F, Bach I.
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| Front Cell Dev Biol. Oct 31;7:258. doi: 10.3389/fcell.2019.00258. 2019
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| 4 | MRX61, RLIM
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| Pathogenic variants in E3 ubiquitin ligase RLIM/RNF12 lead to a syndromic X-linked intellectual disability and behavior disorder.
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| Frints SGM, Ozanturk A, Rodríguez Criado G, Grasshoff U, de Hoon B, Field M, Manouvrier-Hanu S, E Hickey S, Kammoun M, Gripp KW, Bauer C, Schroeder C, Toutain A, Mihalic Mosher T, Kelly BJ, White P, Dufke A, Rentmeester E, Moon S, Koboldt DC, van Roozendaal KEP, Hu H, Haas SA, Ropers HH, Murray L, Haan E, Shaw M, Carroll R, Friend K, Liebelt J, Hobson L, De Rademaeker M, Geraedts J, Fryns JP, Vermeesch J, Raynaud M, Riess O, Gribnau J, Katsanis N, Devriendt K, Bauer P, Gecz J, Golzio C, Gontan C, Kalscheuer VM.
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| Mol Psychiatry. Nov;24(11):1748-1768. doi: 10.1038/s41380-018-0065-x. Epub 2018 May 4 2019
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| 5 | RLIM
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| RNF12 X-Linked Intellectual Disability Mutations Disrupt E3 Ligase Activity and Neural Differentiation.
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| Bustos F, Segarra-Fas A, Chaugule VK, Brandenburg L, Branigan E, Toth R, Macartney T, Knebel A, Hay RT, Walden H, Findlay GM.
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| Cell Rep. May 8;23(6):1599-1611. doi: 10.1016/j.celrep.2018.04.022. 2018
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| 6 | LDB1, LHX2, RLIM
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| Ldb1- and Rnf12-dependent regulation of Lhx2 controls the relative balance between neurogenesis and gliogenesis in the retina.
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| de Melo J, Clark BS, Venkataraman A, Shiau F, Zibetti C, Blackshaw S.
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| Development Apr 30;145(9):dev159970. doi: 10.1242/dev.159970 2018
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| 7 | RLIM
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| Rlim-Dependent and -Independent Pathways for X Chromosome Inactivation in Female ESCs.
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| Wang F, McCannell KN, Boković A, Zhu X, Shin J, Yu J, Gallant J, Byron M, Lawrence JB, Zhu LJ, Jones SN, Rando OJ, Fazzio TG, Bach I.
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| Cell Rep. Dec 26;21(13):3691-3699. doi: 10.1016/j.celrep.2017.12.004 2017
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| 8 | MRX61, RLIM
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| X-exome sequencing of 405 unresolved families identifies seven novel intellectual disability genes.
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| Hu H, Haas SA, Chelly J, Van Esch H, Raynaud M, de Brouwer AP, Weinert S, Froyen G, Frints SG, Laumonnier F, Zemojtel T, Love MI, Richard H, Emde AK, Bienek M, Jensen C, Hambrock M, Fischer U, Langnick C, Feldkamp M, Wissink-Lindhout W, Lebrun N, Castelnau L, Rucci J, Montjean R, Dorseuil O, Billuart P, Stuhlmann T, Shaw M, Corbett MA, Gardner A, Willis-Owen S, Tan C, Friend KL, Belet S, van Roozendaal KE, Jimenez-Pocquet M, Moizard MP, Ronce N, Sun R, O'Keeffe S, Chenna R, van Bömmel A, Göke J, Hackett A, Field M, Christie L, Boyle J, Haan E, Nelson J, Turner G, Baynam G, Gillessen-Kaesbach G, Müller U, Steinberger D, Budny B, Badura-Stronka M, Latos-Bieleńska A, Ousager LB, Wieacker P, Rodríguez Criado G, Bondeson ML, Annerén G, Dufke A, Cohen M, Van Maldergem L, Vincent-Delorme C, Echenne B, Simon-Bouy B, Kleefstra T, Willemsen M, Fryns JP, Devriendt K, Ullmann R, Vingron M, Wrogemann K, Wienker TF, Tzschach A, van Bokhoven H, Gecz J, Jentsch TJ, Chen W, Ropers HH, Kalscheuer VM.
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| Mol Psychiatry 21(1):133-48. doi: 10.1038/mp.2014.193. Epub 2015 Feb 3.
2016
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| 9 | RLIM
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| E3 Ubiquitin Ligase RLIM Negatively Regulates c-Myc Transcriptional Activity and Restrains Cell Proliferation.
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| Gao R, Wang L, Cai H, Zhu J, Yu L.
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| PLoS One. Sep 29;11(9):e0164086. doi: 10.1371/journal.pone.0164086. eCollection 2016 2016
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| 10 | MRX61, RLIM
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| Syndromic X-linked intellectual disability segregating with a missense variant in RLIM.
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| Třnne E, Holdhus R, Stansberg C, Stray-Pedersen A, Petersen K, Brunner HG, Gilissen C, Hoischen A, Prescott T, Steen VM, Fiskerstrand T.
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| Eur J Hum Genet 23(12):1652-6. doi: 10.1038/ejhg.2015.30. Epub 2015 Mar 4.
2015
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| 11 | RLIM
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| The trans-activator RNF12 and cis-acting elements effectuate X chromosome inactivation independent of X-pairing.
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| Barakat TS, Loos F, van Staveren S, Myronova E, Ghazvini M, Grootegoed JA, Gribnau J.
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| Mol Cell 53(6):965-78. doi: 10.1016/j.molcel.2014.02.006. Epub 2014 Mar 6.
2014
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| 12 | RLIM
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| Functional activity of RLIM/Rnf12 is regulated by phosphorylation-dependent nucleocytoplasmic shuttling.
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| Jiao B, Taniguchi-Ishigaki N, Güngör C, Peters MA, Chen YW, Riethdorf S, Drung A, Ahronian LG, Shin J, Pagnis R, Pantel K, Tachibana T, Lewis BC, Johnsen SA, Bach I.
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| Mol Biol Cell 24(19):3085-96. doi: 10.1091/mbc.E13-05-0239. Epub 2013 Jul 31.
2013
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| 13 | REXO1, RLIM
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| Releasing the break on X chromosome inactivation: Rnf12/RLIM targets REX1 for degradation.
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| Bach I.
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| Cell Res 22(11):1524-6. doi: 10.1038/cr.2012.98. Epub 2012 Jun 26.
2012
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| 14 | RLIM
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| Paternal RLIM/Rnf12 is a survival factor for milk-producing alveolar cells.
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| Jiao B, Ma H, Shokhirev MN, Drung A, Yang Q, Shin J, Lu S, Byron M, Kalantry S, Mercurio AM, Lawrence JB, Hoffmann A, Bach I.
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| Cell 149(3):630-41. doi: 10.1016/j.cell.2012.02.056.
2012
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| 15 | RLIM
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| RNF12 activates Xist and is essential for X chromosome inactivation.
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| Barakat TS, Gunhanlar N, Pardo CG, Achame EM, Ghazvini M, Boers R, Kenter A, Rentmeester E, Grootegoed JA, Gribnau J.
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| PLoS Genet 7(1):e1002001.
2011
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| 16 | RLIM, TSIX
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| The X-inactivation trans-activator Rnf12 is negatively regulated by pluripotency factors in embryonic stem cells.
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| Navarro P, Moffat M, Mullin NP, Chambers I.
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| Hum Genet 130(2):255-64. Epub 2011 May 5.
2011
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| 17 | RLIM, SMURF2
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| RLIM interacts with Smurf2 and promotes TGF-β induced U2OS cell migration.
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| Huang Y, Yang Y, Gao R, Yang X, Yan X, Wang C, Jiang S, Yu L.
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| Biochem Biophys Res Commun 414(1):181-5. Epub 2011 Sep 17.
2011
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| 18 | FBXO1, RLIM, TERF1
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| Ubiquitin Ligase RLIM Modulates Telomere Length Homeostasis through a Proteolysis of TRF1.
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| Her YR, Chung IK.
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| J Biol Chem 284(13):8557-66. Epub 2009 Jan 21.
2009
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| 19 | PDLIM1, RLIM
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| Regulation of estrogen-dependent transcription by the LIM cofactors CLIM and RLIM in breast cancer.
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| Johnsen SA, Güngör C, Prenzel T, Riethdorf S, Riethdorf L, Taniguchi-Ishigaki N, Rau T, Tursun B, Furlow JD, Sauter G, Scheffner M, Pantel K, Gannon F, Bach I.
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| Cancer Res 69(1):128-36.
2009
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| 20 | RLIM
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| RNF12 is an X-Encoded dose-dependent activator of X chromosome inactivation.
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| Jonkers I, Barakat TS, Achame EM, Monkhorst K, Kenter A, Rentmeester E, Grosveld F, Grootegoed JA, Gribnau J.
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| Cell 139(5):999-1011.PMID: 19945382 2009
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| 21 | LDB1, RLIM
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| Selective degradation of excess Ldb1 by Rnf12/RLIM confers proper Ldb1 expression levels and Xlim-1/Ldb1 stoichiometry in Xenopus organizer functions.
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| Hiratani I, Yamamoto N, Mochizuki T, Ohmori SY, Taira M.
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| Development 130(17):4161-75.
2003
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| 22 | RLIM
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| Ubiquitination-dependent cofactor exchange on LIM homeodomain transcription factors.
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| Ostendorff HP, Peirano RI, Peters MA, Schlüter A, Bossenz M, Scheffner M, Bach I.
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| Nature 416(6876):99-103.
2002
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| 23 | RLIM
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| RLIM inhibits functional activity of LIM homeodomain transcription factors via recruitment of the histone deacetylase complex.
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| Bach I, Rodriguez-Esteban C, Carričre C, Bhushan A, Krones A, Rose DW, Glass CK, Andersen B, Izpisúa Belmonte JC, Rosenfeld MG.
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| Nat Genet 22(4):394-9.PMID: 10431247 1999
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