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FLASH GENE
Symbol STMN3 contributors: mct/shn - updated : 03/03/2012
HGNC name stathmin-like 3
HGNC id 15926
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal likely involved in membrane attachment
  • a C terminal stathmin like domain
    • HOMOLOGY
    interspecies ortholog to Stmn3, Mus musculus
    ortholog to Stmn3, Rattus norvegicus
    intraspecies homolog to SCG10
    Homologene
    FAMILY stathmin/oncoprotein 18 family of microtubule-destabilizing phosphoproteins
    CATEGORY regulatory , signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic
    text
  • at least partially associated to the Golgi apparatus
  • colocalized to the Golgi apparatus of chromaffin cells and shared localization with CHGA as it transited the Golgi
    • basic FUNCTION
  • able to depolymerize interphase microtubules when overexpressed
  • acts as microtubule destabilizers
  • playing a role in differentiated neurons
  • regulator of axonal branching in hippocampal neurons, and having a function in axonal morphogenesis
  • implicated in the development and functional regulation of various organs, most notably the nervous system
  • participate in the control of microtubule dynamics and may be involved in the control of neuronal differentiation
  • STMN2 and STMN3, interact with CHGA, share partial colocalization in the Golgi apparatus, and may be necessary for typical transmitter storage and release from chromaffin cells
  • crucial for both the formation and proper development of Purkinje cell dendritic arbors
  • novel and specific factor that controls the early phases of Purkinje cell dendritic differentiation during cerebellum development
  • palmitoylation of stathmins 3 likely occurs at the Golgi and is crucial for its specific subcellular localization and trafficking (
    • CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    text signal transduction and regulation of microtubule dynamics
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • is a novel RASGRF1-interacting protein, and influences the signaling properties of RASGRF1
  • CHGA and STMN2 (
  • STAT3 (
  • DHHC3, DHHC7, DHHC15, and DHHC17 (
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS