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FLASH GENE

Symbol

STMN3

contributors: mct/shn - updated : 03/03/2012

HGNC name	stathmin-like 3
HGNC id	15926

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_015894 5 - 2255 NP_056978 21 180 Neuron specific 1998 9603203

EXPRESSION

Type	ubiquitous

expressed in

(based on citations)

organ(s)

System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       moderately Homo sapiens Digestive intestine large intestine colon   moderately Homo sapiens   liver       lowly Homo sapiens   salivary gland       lowly Homo sapiens Endocrine adrenal gland       moderately Homo sapiens   pancreas       moderately Homo sapiens   thyroid       highly Homo sapiens Lymphoid/Immune spleen       moderately Homo sapiens   thymus       highly Homo sapiens Nervous brain hindbrain cerebellum   highly Homo sapiens   brain       highly Homo sapiens   spinal cord       highly Homo sapiens Reproductive female system ovary     moderately Homo sapiens   female system placenta     moderately Homo sapiens   female system uterus     moderately Homo sapiens   female system breast     moderately Homo sapiens   male system testis     moderately Homo sapiens   male system prostate     moderately Homo sapiens Urinary kidney       moderately Homo sapiens

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow     moderately Homo sapiens Muscular striatum skeletal   lowly Homo sapiens Nervous       specific

cells

System Cell Pubmed Species Stage Rna symbol Nervous neuron Nervous Purkinje cell Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

embryo

Text	fetal brain, liver (
	strongly expressed in Purkinje cells during cerebellar development and accumulates in their dendritic processes at a critical period of their formation and outgrowth

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a N terminal likely involved in membrane attachment
	a C terminal stathmin like domain

HOMOLOGY

interspecies	ortholog to Stmn3, Mus musculus
	ortholog to Stmn3, Rattus norvegicus

intraspecies

homolog to SCG10

Homologene

FAMILY

stathmin/oncoprotein 18 family of microtubule-destabilizing phosphoproteins

CATEGORY

regulatory , signaling

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,Golgi
	intracellular,cytoplasm,cytosolic
text	at least partially associated to the Golgi apparatus
	colocalized to the Golgi apparatus of chromaffin cells and shared localization with CHGA as it transited the Golgi

basic FUNCTION	able to depolymerize interphase microtubules when overexpressed
	acts as microtubule destabilizers
	playing a role in differentiated neurons
	regulator of axonal branching in hippocampal neurons, and having a function in axonal morphogenesis
	implicated in the development and functional regulation of various organs, most notably the nervous system
	participate in the control of microtubule dynamics and may be involved in the control of neuronal differentiation
	STMN2 and STMN3, interact with CHGA, share partial colocalization in the Golgi apparatus, and may be necessary for typical transmitter storage and release from chromaffin cells
	crucial for both the formation and proper development of Purkinje cell dendritic arbors
	novel and specific factor that controls the early phases of Purkinje cell dendritic differentiation during cerebellum development
	palmitoylation of stathmins 3 likely occurs at the Golgi and is crucial for its specific subcellular localization and trafficking (

CELLULAR PROCESS

cell organization/biogenesis

PHYSIOLOGICAL PROCESS

text	signal transduction and regulation of microtubule dynamics

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	is a novel RASGRF1-interacting protein, and influences the signaling properties of RASGRF1
	CHGA and STMN2 (
	STAT3 (
	DHHC3, DHHC7, DHHC15, and DHHC17 (

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS