Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol AKAP8L contributors: mct - updated : 24-08-2011
HGNC name A kinase (PRKA) anchor protein 8-like
HGNC id 29857
Location 19p13.12      Physical location : 15.490.858 - 15.529.833
Synonym name
  • neighbor of A-kinase anchoring protein 95
  • helicase A-binding protein 95 kDa
    • Synonym symbol(s) NAKAP95, HAP95, NAKAP
    DNA
    TYPE functioning gene
    STRUCTURE 38.97 kb     14 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    14 - 2136 - 646 - 2007 17594903
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text pancreas
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • potential nuclear localization signal
  • two C2H2 tyep zinc finger motifs
    • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text
  • shuttles between nucleus and cytoplasm
  • localized to the nucleus in interphase, where it primarily associates with the nuclear matrix
    • basic FUNCTION
  • playing a role in constitutive transport element(CTE)- medated gene expression
  • role in DNA replication by providing a scaffold for MCM2
  • having a ubiquitin ligase activity and may be involved in cell growth control potentially through the interaction with AKAP8L
    • CELLULAR PROCESS protein
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • C-terminus of RNA-helicase A
  • interacting with PRPF40A (AKAP8L/PRPF40A scaffold is a potential nuclear docking site for huntingtin protein and may contribute to the nuclear accumulation of huntingtin observed in Huntington disease)
  • RNF43-interacting protein
  • nuclear PRKACA, and PRKACB co-locates with AKAP8L in SFCs (splicing factor compartments) and regulates pre-mRNA splicing, possibly through a cAMP-independent mechanism
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS