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FLASH GENE

Symbol

FZR1

contributors: mct - updated : 25-09-2024

HGNC name	fizzy/cell division cycle 20 related 1 (Drosophila)
HGNC id	24824

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_016263 14 - 5178 NP_057347 - 493 - 2000 10793135 NM_001136197 11 - 3170 NP_001129669 - 404 - 2000 10793135 NM_001136198 12 - 3446 NP_001129670 - 496 - 2000 10793135

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

seven WD repeats (Trp-Asp domains)

HOMOLOGY

interspecies

homolog to yeast cdh1/hct1

Homologene

FAMILY

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic
	intracellular,nucleus,nucleoplasm
	intracellular,nuclear envelope

basic FUNCTION	essential for cyclosome activity in G1
	activating the anaphase promoting complex (APC) by promoting APC cyclin ubiquitination activity
	targeting specific substrates lacking the D box in G1 (such as polo-like kinase for ubiquitination)
	APC/C coactivator protein involved in ubiquitination and down-regulating the stability of TRIB3 protein
	is an essential regulator of spermatogonial proliferation and early meiotic prophase I in both male and female germ cells and is therefore important in establishing the reproductive health of adult male and female mammals
	FZR1 regulates E2F1 degradation in response to differentiation signals in keratinocytes
	reciprocal suppression mechanism between FZR1 and BRAF in controlling tumorigenesis
	reciprocal feedback circuit of FZR1 and SRC in the crosstalk between the cell cycle machinery and the SRC signaling pathway
	FZR1-FOXM1-APC axis functions as a key regulator of muscle development and regeneration

CELLULAR PROCESS	cell cycle
	protein, degradation
	protein, ubiquitin dependent proteolysis

PHYSIOLOGICAL PROCESS

development

text	substrate-specific APC/C activators
	controlling axonal growth and the patterning of mammalian brain

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	APC/C complex
	mediating its own degradation
	MAK associates with FZR1, and phosphorylates FZR1 at sites phosphorylated by cyclin-dependent kinases
	is an activator of the Anaphase promoting complex/cyclosome (APC/C) and an important regulator of the mitotic cell division cycle
	FZR1 is a direct target of ERK and CYCLIN D1/CDK4 kinases
	FZR1 suppresses AURKA activity in interphase and is critically required for assembly of the interphase mitochondrial network after mitosis
	FZR1 ubiquitinates IDH2, a major NADPH-producing enzyme in mitochondria contributing to ROS increase in mitosis

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

DEE109

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS