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FLASH GENE
Symbol FZR1 contributors: mct - updated : 16-02-2013
HGNC name fizzy/cell division cycle 20 related 1 (Drosophila)
HGNC id 24824
DNA
TYPE functioning gene
STRUCTURE 11.00 kb     13 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
seven WD repeats (Trp-Asp domains)
HOMOLOGY
interspecies homolog to yeast cdh1/hct1
Homologene
FAMILY
CATEGORY regulatory
SUBCELLULAR LOCALIZATION
basic FUNCTION
  • essential for cyclosome activity in G1
  • activating the anaphase promoting complex (APC) by promoting APC cyclin ubiquitination activity
  • targeting specific substrates lacking the D box in G1 (such as polo-like kinase for ubiquitination)
  • APC/C coactivator protein involved in ubiquitination and down-regulating the stability of TRIB3 protein
  • CELLULAR PROCESS cell cycle
    protein, degradation
    protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS development
    text
  • substrate-specific APC/C activators
  • controlling axonal growth and the patterning of mammalian brain
  • PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • APC/C complex
  • mediating its own degradation
  • MAK associates with FZR1, and phosphorylates FZR1 at sites phosphorylated by cyclin-dependent kinases
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS