| Symbol
| DKK1
| contributors: mct/npt/pgu - updated : 07-08-2018
|
| HGNC name
| dickkopf homolog 1 (Xenopus laevis)
|
| HGNC id
| 2891
|
| Other morbid association(s)
|
| Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
|---|
| tumoral
|
|
| --over
|
| |
in prostate carcinoma | | tumoral
|
|
| --over
|
| |
in bone marrow plasma and peripheral blood is associated with the presence of osteolytic bone lesions in multiple myeloma | | tumoral
|
|
| --low
|
| |
in colon cancer | | constitutional
|
|
| --over
|
| |
in arthritis is mediated by TNF-induced activation of MAPK14 signaling | | tumoral
|
|
|
|
| |
in placental choriocarcinoma | | tumoral
|
|
|
| loss of function
|
contribute to epithelial ovarian cancer progression, metastasis, and chemoresistance  | |
Variant & Polymorphism
| 
| |
Candidate gene
Marker
Therapy target
|
|
| System | Type | Disorder | Pubmed |
|---|
| cancer | reproductive | placenta | |
| target in treatment of placental choriocarcinomas | | cardiovascular | | | |
| DKK1 antagonists or drugs that rescue the Wnt pathway might be neuroprotective in stroke | | cancer | hemopathy | | |
| potentially important antigen for immunotherapy in multiple myeloma | | osteoarticular | bone | ostéoporosis | |
| sclerostin and DKK1 are emerging as the leading new targets for anabolic therapies to treat bone diseases such as osteoporosis and for bone repair |
| | | |
|
| Dkk1-null mutant embryos display severe defects in head induction |