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FLASH GENE
Symbol DKK1 contributors: mct/npt/pgu - updated : 07-08-2016
HGNC name dickkopf homolog 1 (Xenopus laevis)
HGNC id 2891
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
in prostate carcinoma
tumoral     --over  
in bone marrow plasma and peripheral blood is associated with the presence of osteolytic bone lesions in multiple myeloma
tumoral     --low  
in colon cancer
constitutional     --over  
in arthritis is mediated by TNF-induced activation of MAPK14 signaling
tumoral        
in placental choriocarcinoma
tumoral       loss of function
contribute to epithelial ovarian cancer progression, metastasis, and chemoresistance
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
SystemTypeDisorderPubmed
cancerreproductiveplacenta
target in treatment of placental choriocarcinomas
cardiovascular  
DKK1 antagonists or drugs that rescue the Wnt pathway might be neuroprotective in stroke
cancerhemopathy 
potentially important antigen for immunotherapy in multiple myeloma
osteoarticularboneostéoporosis
sclerostin and DKK1 are emerging as the leading new targets for anabolic therapies to treat bone diseases such as osteoporosis and for bone repair
ANIMAL & CELL MODELS
Dkk1-null mutant embryos display severe defects in head induction