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FLASH GENE
Symbol GPR26 contributors: mct - updated : 12-03-2019
HGNC name G protein-coupled receptor 26
HGNC id 4481
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain     Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Nervouscentral   
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo
Text in developing brain
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • seven predicted transmembrane domains
  • a short N terminus lacking the potential N-linked glycosylation site typical of other GPRs
  • a pair of cationic residues corresponding to cationic residues conserved in purinergic P2Y receptors
    • HOMOLOGY
    interspecies homolog to rattus GPR26
    intraspecies homolog to HTR5A
    homolog to BB2
    Homologene
    FAMILY
  • G-protein coupled receptor 1 family
    • CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
    text exclusively in brain
    basic FUNCTION
  • activate G proteins in a manner that is distinct from other group 1 GPCRs
  • could be a suppressor of primary glioblastoma development
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    significantly less transcribed in glioblastoma tissues from older patients
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS