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FLASH GENE

Symbol

GPR26

contributors: mct - updated : 12-03-2019

HGNC name	G protein-coupled receptor 26
HGNC id	4481

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	10q26.13      Physical location : 125.425.870 - 125.456.911
Synonym symbol(s)	MGC138216, DKFZp761H2121, FLJ33774

DNA

TYPE	functioning gene
STRUCTURE	31.05 kb     3 Exon(s)

10 Kb 5' upstream gene genomic sequence study

motif

repetitive sequence   ALU   long interspersed repetitive elements

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_153442 3 - 10316 NP_703143 37.5 337 - 2002 11854302

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain         Homo sapiens

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Nervous central

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

embryo

Text	in developing brain

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	seven predicted transmembrane domains
	a short N terminus lacking the potential N-linked glycosylation site typical of other GPRs
	a pair of cationic residues corresponding to cationic residues conserved in purinergic P2Y receptors

HOMOLOGY

interspecies

homolog to rattus GPR26

intraspecies	homolog to HTR5A
	homolog to BB2

Homologene

FAMILY

G-protein coupled receptor 1 family

CATEGORY

receptor membrane G

SUBCELLULAR LOCALIZATION	plasma membrane
text	exclusively in brain

basic FUNCTION	activate G proteins in a manner that is distinct from other group 1 GPCRs
	could be a suppressor of primary glioblastoma development

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

signal transduction

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   significantly less transcribed in glioblastoma tissues from older patients

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS