| Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
|---|
| tumoral
|
|
|
| loss of function
|
|
by hypermethylation in breast and thyroid carcinoma or HNSCC, pediatric tumors, clear cell and papillary renal cell carcinoma, testicular germ cell tumor, cholangiocarcinoma and prostate carcinoma |
| tumoral
|
|
|
| loss of function
|
|
by promoter methylation in lung and colorectal cancer, in Wilms tumor and in glioma |
| tumoral
|
|
|
| loss of function
|
|
by hypermethylation in medulloblastoma, hepatocellular carcinomas, cholangiocarcinomas and cervical carcinoma |
| tumoral
|
| deletion
|
|
|
|
in lung, breast, renal cell carcinomas (see DLEC1) and HNSCC |
| tumoral
|
|
|
| loss of function
|
|
frequent in pancreatic cancer and suggesting an inverse correlation between RASSF1A silencing and K-ras activation in pancreatic cancer |
| tumoral
|
|
|
| loss of function
|
|
hypermethylation of the promoter associated with a poor prognosis in non small cell lung cancer in patients starting cigarette smoking at an early age |
| tumoral
|
|
| --low
|
|
|
by promoter methylation in adenoid cystic carcinoma of the salivary gland, high-grade tumors and tumors with metastasis |
| tumoral
|
|
| --low
|
|
by DNA hypermethylation may be involved in Gallblader carcinogenesis  |
| tumoral
|
|
| --low
|
|
|
by promoter hypermethylation in parathyroid tumours |
| constitutional
|
|
| --over
|
|
|
inhibits centrosome separation |
| tumoral
|
|
| --low
|
|
|
more pronounced in cervical tumors with lymph node metastases compared with non-metastatic ones |
