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FLASH GENE
Symbol RASSF1 contributors: mct/npt/pgu - updated : 03-09-2018
HGNC name Ras association (RalGDS/AF-6) domain family member 1
HGNC id 9882
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral       loss of function
by hypermethylation in breast and thyroid carcinoma or HNSCC, pediatric tumors, clear cell and papillary renal cell carcinoma, testicular germ cell tumor, cholangiocarcinoma and prostate carcinoma
tumoral       loss of function
by promoter methylation in lung and colorectal cancer, in Wilms tumor and in glioma
tumoral       loss of function
by hypermethylation in medulloblastoma, hepatocellular carcinomas, cholangiocarcinomas and cervical carcinoma
tumoral   deletion    
in lung, breast, renal cell carcinomas (see DLEC1) and HNSCC
tumoral       loss of function
frequent in pancreatic cancer and suggesting an inverse correlation between RASSF1A silencing and K-ras activation in pancreatic cancer
tumoral       loss of function
hypermethylation of the promoter associated with a poor prognosis in non small cell lung cancer in patients starting cigarette smoking at an early age
tumoral     --low  
by promoter methylation in adenoid cystic carcinoma of the salivary gland, high-grade tumors and tumors with metastasis
tumoral     --low  
by DNA hypermethylation may be involved in Gallblader carcinogenesis
tumoral     --low  
by promoter hypermethylation in parathyroid tumours
constitutional     --over  
inhibits centrosome separation
tumoral     --low  
more pronounced in cervical tumors with lymph node metastases compared with non-metastatic ones
Susceptibility to lung adenocarcinoma by tobacco smoker during adolescence
Variant & Polymorphism SNP , other
  • starting smoking under age 18 was significantly related to RASSF1A methylation in lung adenocarcinoma
  • at codon 133 preferentially associated with lung adenocarcinoma risk
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Rassf1a(-/-) mice are prone to both spontaneous and carcinogen-induced tumorigenesis