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FLASH GENE

Symbol

FLG

contributors: mct/npt/pgu - updated : 16-05-2018

HGNC name	filaggrin
HGNC id	3748

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

IVLG

Susceptibility

to atopic dermatis, for the extrinsic subtype of AD, and with concomitant respiratory allergic diseases

Variant & Polymorphism other	R510X and 2282del4 are very strong predisposing factors for atopic dermatitis
	four prevalent mutations (R501X, 2282del4, R2447X and S3247X)strongly associated to atopic dermatis

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS