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FLASH GENE
Symbol FLG contributors: mct/npt/pgu - updated : 16-05-2018
HGNC name filaggrin
HGNC id 3748
ASSOCIATED DISORDERS
corresponding disease(s) IVLG
Susceptibility
  • to atopic dermatis, for the extrinsic subtype of AD, and with concomitant respiratory allergic diseases
  • Variant & Polymorphism other
  • R510X and 2282del4 are very strong predisposing factors for atopic dermatitis
  • four prevalent mutations (R501X, 2282del4, R2447X and S3247X)strongly associated to atopic dermatis
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS