basic FUNCTION
| involved in intestinal absorption and intracellular cholesterol transport |
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required for intestinal uptake of both cholesterol and phytosterols and playing a major role in cholesterol |
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involved in an ezetimibe-sensitive pathway for cholesterol uptake |
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has the ability to transport alpha-tocopherol  |
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play an essential role in intestinal cholesterol absorption  |
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mediates cholesterol uptake through vesicular endocytosis, and NPC1L1 recycles between endocytic recycling compartment (ERC) and plasma membrane (PM) in responding to cellular cholesterol alterations |
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mediates intestinal cholesterol absorption and it may also limit hepatobiliary cholesterol excretion  |
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essential protein for dietary cholesterol absorption  |
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mediates cholesterol uptake via vesicular endocytosis  |
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playing a crucial role in dietary and biliary cholesterol absorption  |
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senses cholesterol through direct binding by its NTD, then cholesterol may be transferred to local membrane to form the NPC1L1-flotillin-cholesterol membrane microdomain, which is internalized via the clathrin-AP2 pathway  |
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function of NPC1L1 in reabsorbing biliary cholesterol was impaired when hepatic CDC42 was deleted  |