Citations for
1NPC1L1, PYY
Modulatory role of PYY in transport and metabolism of cholesterol in intestinal epithelial cells.
Grenier E, Garofalo C, Delvin E, Levy E.
PLoS One 7(7):e40992. doi: 10.1371/journal.pone.0040992. Epub 2012 Jul 23. 2012
2NPC1L1
Molecular characterization of the NPC1L1 variants identified from cholesterol low absorbers.
Wang LJ, Wang J, Li N, Ge L, Li BL, Song BL.
J Biol Chem 286(9):7397-408. Epub 2010 Dec 28. 2011
3NPC1L1
The N-terminal domain of NPC1L1 protein binds cholesterol and plays essential roles in cholesterol uptake.
Zhang JH, Ge L, Qi W, Zhang L, Miao HH, Li BL, Yang M, Song BL.
J Biol Chem 286(28):25088-97. Epub 2011 May 20. 2011
4CDC42, NPC1L1
The small GTPase Cdc42 interacts with Niemann-Pick C1-like 1 (NPC1L1) and controls its movement from endocytic recycling compartment to plasma membrane in a cholesterol-dependent manner.
Xie C, Li N, Chen ZJ, Li BL, Song BL.
J Biol Chem 286(41):35933-42. doi: 10.1074/jbc.M111.270199. Epub 2011 Aug 15. 2011
5FLOT1, FLOT2, NPC1L1
Flotillins play an essential role in Niemann-Pick C1-like 1-mediated cholesterol uptake.
Ge L, Qi W, Wang LJ, Miao HH, Qu YX, Li BL, Song BL.
Proc Natl Acad Sci U S A 108(2):551-6. doi: 10.1073/pnas.1014434108. Epub 2010 Dec 27. 2011
6NPC1L1
NPC1L1 and cholesterol transport.
Betters JL, Yu L.
FEBS Lett 584(13):2740-7. Epub 2010 Mar 19. Review.PMID: 20307540 2010
7NPC1L1
An NPC1L1 gene promoter variant is associated with autosomal dominant hypercholesterolemia.
Martín B, Solanas-Barca M, García-Otín AL, Pampín S, Cofán M, Ros E, Rodríguez-Rey JC, Pocoví M, Civeira F.
Nutr Metab Cardiovasc Dis 20(4):236-42. Epub 2009 Sep 11.PMID: 19747803 2010
8HNF1A, NPC1L1
HNF1alpha and SREBP2 are important regulators of NPC1L1 in human liver.
Pramfalk C, Jiang ZY, Cai Q, Hu H, Zhang SD, Han TQ, Eriksson M, Parini P.
J Lipid Res 51(6):1354-62. 2010
9HMGCR, NPC1, NPC1L1, SCAP
Membrane topology of human NPC1L1, a key protein in enterohepatic cholesterol absorption.
Wang J, Chu BB, Ge L, Li BL, Yan Y, Song BL.
J Lipid Res 50(8):1653-62. Epub 2009 Mar 26.PMID: 19325169 2009
10NPC1L1
Genetic inactivation of NPC1L1 protects against sitosterolemia in mice lacking ABCG5/ABCG8.
Tang W, Ma Y, Jia L, Ioannou YA, Davies JP, Yu L.
J Lipid Res 50(2):293-300. Epub 2008 Sep 15.PMID: 18796403 2009
11NPC1L1
Functional characterization of genetic variants in NPC1L1 supports the sequencing extremes strategy to identify complex trait genes.
Fahmi S, Yang C, Esmail S, Hobbs HH, Cohen JC.
Hum Mol Genet 17(14):2101-7. Epub 2008 Apr 15. 2008
12NPC1L1
Kinetic imaging of NPC1L1 and sterol trafficking between plasma membrane and recycling endosomes in hepatoma cells.
Petersen NH, Faergeman NJ, Yu L, Wüstner D.
J Lipid Res 49(9):2023-37. Epub 2008 Jun 3. Erratum in: J Lipid Res. 2008 Nov;49(11):2491.. Faegeman, Nils J [corrected to Faergeman, Nils J 2008
13NPC1L1
Niemann-pick C1-like 1 mediates alpha-tocopherol transport.
Narushima K, Takada T, Yamanashi Y, Suzuki H.
Mol Pharmacol 74(1):42-9. Epub 2008 Apr 10.PMID: 18403720 2008
14NPC1L1
Effect of ezetimibe coadministered with statins in genotype-confirmed heterozygous FH patients.
Pisciotta L, Fasano T, Bellocchio A, Bocchi L, Sallo R, Fresa R, Colangeli I, Cantafora A, Calandra S, Bertolini S.
Atherosclerosis 194(2):e116-22. Epub 2006 Nov 30. 2007
15NPC1, NPC1L1
Human NPC1L1 and NPC1 can functionally substitute for the ncr genes to promote reproductive development in C. elegans.
Smith MM, Levitan DJ.
Biochim Biophys Acta 1770(9):1345-51. Epub 2007 Jun 22.PMID: 17662536 2007
16NPC1L1
Multiple rare variants in NPC1L1 associated with reduced sterol absorption and plasma low-density lipoprotein levels.
Cohen JC, Pertsemlidis A, Fahmi S, Esmail S, Vega GL, Grundy SM, Hobbs HH.
Proc Natl Acad Sci U S A 103(6):1810-5. Epub 2006 Jan 31. 2006
17NPC1L1
Niemann-Pick C1 like 1 gene expression is down-regulated by LXR activators in the intestine.
Duval C, Touche V, Tailleux A, Fruchart JC, Fievet C, Clavey V, Staels B, Lestavel S.
Biochem Biophys Res Commun 340(4):1259-63. Epub 2006 Jan 5. 2006
18NPC1L1
Sequence variation in NPC1L1 and association with improved LDL-cholesterol lowering in response to ezetimibe treatment.
Simon JS, Karnoub MC, Devlin DJ, Arreaza MG, Qiu P, Monks SA, Severino ME, Deutsch P, Palmisano J, Sachs AB, Bayne ML, Plump AS, Schadt EE.
Genomics 86(6):648-56. Epub 2005 Nov 16. 2005
19NPC1L1
Niemann-Pick C1 Like 1 protein is critical for intestinal cholesterol absorption.
Altmann SW, Davis HR Jr, Zhu LJ, Yao X, Hoos LM, Tetzloff G, Iyer SP, Maguire M, Golovko A, Zeng M, Wang L, Murgolo N, Graziano MP.
Science 303(5661):1201-4. 2004
20NPC1L1
Niemann-Pick C1 Like 1 (NPC1L1) is the intestinal phytosterol and cholesterol transporter and a key modulator of whole-body cholesterol homeostasis.
Davis HR Jr, Zhu LJ, Hoos LM, Tetzloff G, Maguire M, Liu J, Yao X, Iyer SP, Lam MH, Lund EG, Detmers PA, Graziano MP, Altmann SW.
J Biol Chem 279(32):33586-92. Epub 2004 Jun 1. 2004
21NPC1L1
Evidence for a Niemann-pick C (NPC) gene family: identification and characterization of NPC1L1.
Davies JP, Levy B, Ioannou YA.
Genomics 65(2):137-45. 2000
22NPC1, NPC1L1
The structure and function of the niemann-pick C1 protein.
Ioannou YA.
Mol Genet Metab 71(1-2):175-81. 2000